Anaplastic Plasmacytomas: Relationships to Normal Memory B Cells and Plasma Cell Neoplasms of Immunodeficient and Autoimmune Mice

Overview

Journal J Pathol

Specialty Pathology

Date 2010 Mar 11

PMID 20217872

Citations 6

Authors

Chen-Feng Qi

Dong-Mi Shin

Zhaoyang Li

Hongsheng Wang

Jianxum Feng

Janet W Hartley

Torgny N Fredrickson

Alexander L Kovalchuk

Herbert C Morse 3rd

Affiliations

Soon will be listed here.

Abstract

Anaplastic plasmacytomas (APCTs) from NFS.V(+) congenic mice and pristane-induced plasmacytic PCTs from BALB/c mice were previously shown to be histologically and molecularly distinct subsets of plasma cell neoplasms (PCNs). Here we extended these comparisons, contrasting primary APCTs and PCTs by gene expression profiling in relation to the expression profiles of normal naïve, germinal centre, and memory B cells and plasma cells. We also sequenced immunoglobulin genes from APCT and APCT-derived cell lines and defined surface phenotypes and chromosomal features of the cell lines by flow cytometry and by spectral karyotyping and fluorescence in situ hybridization. The results indicate that APCTs share many features with normal memory cells and the plasma cell-related neoplasms (PLs) of FASL-deficient mice, suggesting that APCTs and PLs are related and that both derive from memory B cells. Published in 2010 by John Wiley & Sons, Ltd.

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