The Golgi and the Centrosome: Building a Functional Partnership

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2010 Mar 10

PMID 20212314

Citations 76

Authors

Christine Sutterlin

Antonino Colanzi

Affiliations

Soon will be listed here.

Abstract

The mammalian Golgi apparatus is characterized by a ribbon-like organization adjacent to the centrosome during interphase and extensive fragmentation and dispersal away from the centrosome during mitosis. It is not clear whether this dynamic association between the Golgi and centrosome is of functional significance. We discuss recent findings indicating that the Golgi-centrosome relationship may be important for directional protein transport and centrosome positioning, which are both required for cell polarization. We also summarize our current knowledge of the link between Golgi organization and cell cycle progression.

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