Age-related Changes in Grey and White Matter Structure Throughout Adulthood

Overview

Journal Neuroimage

Specialty Radiology

Date 2010 Mar 10

PMID 20211265

Citations 244

Authors

Antonio Giorgio

Luca Santelli

Valentina Tomassini

Rose Bosnell

Steve Smith

Nicola De Stefano

Heidi Johansen-Berg

Affiliations

Soon will be listed here.

Abstract

Normal ageing is associated with gradual brain atrophy. Determining spatial and temporal patterns of change can help shed light on underlying mechanisms. Neuroimaging provides various measures of brain structure that can be used to assess such age-related change but studies to date have typically considered single imaging measures. Although there is consensus on the notion that brain structure deteriorates with age, evidence on the precise time course and spatial distribution of changes is mixed. We assessed grey matter (GM) and white matter (WM) structure in a group of 66 adults aged between 23 and 81. Multimodal imaging measures included voxel-based morphometry (VBM)-style analysis of GM and WM volume and diffusion tensor imaging (DTI) metrics of WM microstructure. We found widespread reductions in GM volume from middle age onwards but earlier reductions in GM were detected in frontal cortex. Widespread age-related deterioration in WM microstructure was detected from young adulthood onwards. WM decline was detected earlier and more sensitively using DTI-based measures of microstructure than using markers of WM volume derived from conventional T1-weighted imaging.

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References

Pierpaoli C, Basser P . Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med. 1996; 36(6):893-906. DOI: 10.1002/mrm.1910360612. View

Raz N, Gunning F, Head D, Dupuis J, McQuain J, Briggs S . Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex. 1997; 7(3):268-82. DOI: 10.1093/cercor/7.3.268. View

Peters A, Morrison J, Rosene D, Hyman B . Feature article: are neurons lost from the primate cerebral cortex during normal aging?. Cereb Cortex. 1998; 8(4):295-300. DOI: 10.1093/cercor/8.4.295. View

Paus T, Zijdenbos A, Worsley K, Collins D, Blumenthal J, Giedd J . Structural maturation of neural pathways in children and adolescents: in vivo study. Science. 1999; 283(5409):1908-11. DOI: 10.1126/science.283.5409.1908. View

Salat D, Kaye J, Janowsky J . Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease. Arch Neurol. 1999; 56(3):338-44. DOI: 10.1001/archneur.56.3.338. View

Sowell E, Thompson P, Holmes C, Jernigan T, Toga A . In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nat Neurosci. 1999; 2(10):859-61. DOI: 10.1038/13154. View

Virta A, Barnett A, Pierpaoli C . Visualizing and characterizing white matter fiber structure and architecture in the human pyramidal tract using diffusion tensor MRI. Magn Reson Imaging. 1999; 17(8):1121-33. DOI: 10.1016/s0730-725x(99)00048-x. View

Song S, Yoshino J, Le T, Lin S, Sun S, Cross A . Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage. 2005; 26(1):132-40. DOI: 10.1016/j.neuroimage.2005.01.028. View

Enzinger C, Fazekas F, Matthews P, Ropele S, Schmidt H, Smith S . Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology. 2005; 64(10):1704-11. DOI: 10.1212/01.WNL.0000161871.83614.BB. View

10.

Salat D, Tuch D, Greve D, van der Kouwe A, Hevelone N, Zaleta A . Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging. 2005; 26(8):1215-27. DOI: 10.1016/j.neurobiolaging.2004.09.017. View

11.

Pfefferbaum A, Adalsteinsson E, Sullivan E . Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging. Neuroimage. 2005; 26(3):891-9. DOI: 10.1016/j.neuroimage.2005.02.034. View

12.

Furutani K, Harada M, Minato M, Morita N, Nishitani H . Regional changes of fractional anisotropy with normal aging using statistical parametric mapping (SPM). J Med Invest. 2005; 52(3-4):186-90. DOI: 10.2152/jmi.52.186. View

13.

Walhovd K, Fjell A, Reinvang I, Lundervold A, Dale A, Eilertsen D . Effects of age on volumes of cortex, white matter and subcortical structures. Neurobiol Aging. 2005; 26(9):1261-70. DOI: 10.1016/j.neurobiolaging.2005.05.020. View

14.

Salat D, Tuch D, Hevelone N, Fischl B, Corkin S, Rosas H . Age-related changes in prefrontal white matter measured by diffusion tensor imaging. Ann N Y Acad Sci. 2006; 1064:37-49. DOI: 10.1196/annals.1340.009. View

15.

Riddle D, Sonntag W, Lichtenwalner R . Microvascular plasticity in aging. Ageing Res Rev. 2003; 2(2):149-68. DOI: 10.1016/s1568-1637(02)00064-8. View

16.

Pfefferbaum A, Sullivan E . Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming. Magn Reson Med. 2003; 49(5):953-61. DOI: 10.1002/mrm.10452. View

17.

Rovaris M, Iannucci G, Cercignani M, Sormani M, De Stefano N, Gerevini S . Age-related changes in conventional, magnetization transfer, and diffusion-tensor MR imaging findings: study with whole-brain tissue histogram analysis. Radiology. 2003; 227(3):731-8. DOI: 10.1148/radiol.2273020721. View

18.

Song S, Sun S, Ju W, Lin S, Cross A, Neufeld A . Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 2003; 20(3):1714-22. DOI: 10.1016/j.neuroimage.2003.07.005. View

19.

Wakana S, Jiang H, Nagae-Poetscher L, van Zijl P, Mori S . Fiber tract-based atlas of human white matter anatomy. Radiology. 2003; 230(1):77-87. DOI: 10.1148/radiol.2301021640. View

20.

Sullivan E, Rosenbloom M, Serventi K, Pfefferbaum A . Effects of age and sex on volumes of the thalamus, pons, and cortex. Neurobiol Aging. 2004; 25(2):185-92. DOI: 10.1016/s0197-4580(03)00044-7. View