Nocardia Farcinica Lung Infection in a Patient with Cystic Fibrosis: a Case Report

Overview

Journal J Med Case Rep

Publisher Biomed Central

Specialty General Medicine

Date 2010 Mar 10

PMID 20211000

Citations 10

Authors

Fadi Bittar

Nathalie Stremler

Jean-Pierre Audie

Jean-Christophe Dubus

Jacques Sarles

Didier Raoult

Jean-Marc Rolain

Affiliations

Soon will be listed here.

Abstract

Introduction: Respiratory tract infections are the major causes of morbidity and mortality in patients with cystic fibrosis. Nocardia are rarely implicated in these infections and few reports of the involvement of this species are found in the literature.

Case Presentation: We describe a case of lung infection followed by chronic colonization of trimethoprim and sulfamethoxazole resistant Nocardia farcinica in a patient with cystic fibrosis. The chronic colonization of this uncommon bacterium in patients with cystic fibrosis was proved using a newly developed real-time polymerase chain reaction assay, which indicates that this bacterium, despite treatment, is difficult to eradicate.

Conclusion: Our case report confirms that this organism can be recovered in persons with cystic fibrosis. Its eradication is necessary especially if the patient is to undergo lung transplantation.

Citing Articles

Clinical features and outcomes of persons with cystic fibrosis and nocardia isolation: a systematic review.

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CRISPR/Cas12a-Based Diagnostic Platform Accurately Detects Targeting a Novel Species-Specific Gene.

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Clinical significance, antimicrobial susceptibility and molecular identification of Nocardia species isolated from children with cystic fibrosis.

Betran A, Villuendas M, Rezusta A, Pereira J, Revillo M, Rodriguez-Nava V Braz J Microbiol. 2016; 47(3):531-5.

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Nocardia Colonization: A Risk Factor for Lung Deterioration in Cystic Fibrosis Patients?.

Dagan A, Keller N, Vilozni D, Ramon-Saraf R, Bat-El Bar , Sarouk I Med Sci Monit. 2015; 21:1889-94.

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