Host Determinants of HIV-1 Control in African Americans

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2010 Mar 9

PMID 20205591

Citations 92

Authors

Kimberly Pelak

David B Goldstein

Nicole M Walley

Jacques Fellay

Dongliang Ge

Kevin V Shianna

Curtis Gumbs

Xiaojiang Gao

Jessica M Maia

Kenneth D Cronin

Shehnaz K Hussain

Mary Carrington

Nelson L Michael

Amy C Weintrob

Affiliations

Soon will be listed here.

Abstract

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

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References

Price A, Patterson N, Plenge R, Weinblatt M, Shadick N, Reich D . Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006; 38(8):904-9. DOI: 10.1038/ng1847. View

Pritchard J, Przeworski M . Linkage disequilibrium in humans: models and data. Am J Hum Genet. 2001; 69(1):1-14. PMC: 1226024. DOI: 10.1086/321275. View

Wang K, Li M, Hadley D, Liu R, Glessner J, Grant S . PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res. 2007; 17(11):1665-74. PMC: 2045149. DOI: 10.1101/gr.6861907. View

Shrestha S, Aissani B, Song W, Wilson C, Kaslow R, Tang J . Host genetics and HIV-1 viral load set-point in African-Americans. AIDS. 2009; 23(6):673-7. PMC: 2663898. DOI: 10.1097/QAD.0b013e328325d414. View

Lama J, Planelles V . Host factors influencing susceptibility to HIV infection and AIDS progression. Retrovirology. 2007; 4:52. PMC: 1978541. DOI: 10.1186/1742-4690-4-52. View

Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G . Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1. J Virol. 2002; 76(16):8276-84. PMC: 155130. DOI: 10.1128/jvi.76.16.8276-8284.2002. View

Quinn T, Wawer M, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F . Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med. 2000; 342(13):921-9. DOI: 10.1056/NEJM200003303421303. View

Napravnik S, Poole C, Thomas J, Eron Jr J . Gender difference in HIV RNA levels: a meta-analysis of published studies. J Acquir Immune Defic Syndr. 2002; 31(1):11-9. DOI: 10.1097/00126334-200209010-00002. View

Lewontin R . The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. Genetics. 1964; 49(1):49-67. PMC: 1210557. DOI: 10.1093/genetics/49.1.49. View

10.

Shrestha S, Strathdee S, Galai N, Oleksyk T, Daniele Fallin M, Mehta S . Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. J Infect Dis. 2005; 193(1):16-26. DOI: 10.1086/498532. View

11.

Kruglyak L . Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 1999; 22(2):139-44. DOI: 10.1038/9642. View

12.

de Bakker P, McVean G, Sabeti P, Miretti M, Green T, Marchini J . A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet. 2006; 38(10):1166-72. PMC: 2670196. DOI: 10.1038/ng1885. View

13.

Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M, Bender D . PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007; 81(3):559-75. PMC: 1950838. DOI: 10.1086/519795. View

14.

Fellay J, Shianna K, Ge D, Colombo S, Ledergerber B, Weale M . A whole-genome association study of major determinants for host control of HIV-1. Science. 2007; 317(5840):944-7. PMC: 1991296. DOI: 10.1126/science.1143767. View

15.

Ge D, Fellay J, Thompson A, Simon J, Shianna K, Urban T . Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009; 461(7262):399-401. DOI: 10.1038/nature08309. View

16.

Migueles S, Sabbaghian M, Shupert W, Bettinotti M, Marincola F, Martino L . HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci U S A. 2000; 97(6):2709-14. PMC: 15994. DOI: 10.1073/pnas.050567397. View

17.

Kiepiela P, Leslie A, Honeyborne I, Ramduth D, Thobakgale C, Chetty S . Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature. 2004; 432(7018):769-75. DOI: 10.1038/nature03113. View