Endoscopic Resection of Small Gastrointestinal Stromal Tumors

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2010 Mar 6

PMID 20204697

Citations 17

Authors

Jianying Bai

Yiqin Wang

Hong Guo

Pengbin Zhang

Xianlong Ling

Xiaoyan Zhao

Affiliations

Soon will be listed here.

Abstract

Background: The common treatment principle of gastrointestinal stromal tumors (GISTs) is complete resection of the tumor. The rapid development of endoscopic skill makes it possible to resect GISTs en-bloc through the endoscopic approach.

Aims: The aim of this study is to evaluate the feasibility of endoscopic resection for small-size (<30 mm) gastric GISTs.

Methods: A total of 25 patients with gastric GISTs underwent endoscopic resection assisted with needle knife, loop, and snare. Clinical data, perioperative outcomes, tumor size and microscopic characteristics, immunohistochemical staining results, and follow-up outcomes were recorded.

Results: Endoscopic resection was successfully accomplished in 25 patients at age of 56.72 +/- 11.42 years. The average operation time was 58.52 +/- 21.84 min. Perforation for 2-6 mm occurred in seven patients (28%) and was closed well with clips, with no conversions to open surgery. No mortalities occurred. All tumors were located in the stomach, and had an average size of (11.64 +/- 6.12) mm (5-30 mm). The average length of hospitalization was 4.28 +/- 0.84 days. Out of the total of 25 patients, 21 (84%) were at very low risk and only one (4%) was at intermediate risk. Positive rate of CD117 and CD34 was 92 and 84%, respectively. A follow-up for 11.44 +/- 5.79 months (2-23 months) showed no recurrence or metastasis.

Conclusions: Endoscopic resection is feasible, safe, and effective for small-size gastric GISTs (<30 mm). Short-term follow-up evaluation merits favorable clinical results.

Citing Articles

Efficacy of endoscopic ultrasound in the evaluation of small gastrointestinal stromal tumors.

Ge Q, Wu Y, Liu Z, Wang Z, Wang S, Liu X World J Gastroenterol. 2022; 28(37):5457-5468.

PMID: 36312832 PMC: 9611709. DOI: 10.3748/wjg.v28.i37.5457.

Sealing the hole: endoscopic management of acute gastrointestinal perforations.

Gabr A Frontline Gastroenterol. 2019; 11(1):55-61.

PMID: 31885841 PMC: 6914298. DOI: 10.1136/flgastro-2018-101136.

Omental Patching and Purse-String Endosuture Closure after Endoscopic Full-Thickness Resection in Patients with Gastric Gastrointestinal Stromal Tumors.

Inayat F, Aslam A, Grunwald M, Hussain Q, Hurairah A, Iqbal S Clin Endosc. 2018; 52(3):283-287.

PMID: 30300981 PMC: 6547348. DOI: 10.5946/ce.2018.116.

Long-term outcomes of endoscopic resection of gastric GISTs.

Yu C, Liao G, Fan C, Yu J, Nie X, Yang S Surg Endosc. 2017; 31(11):4799-4804.

PMID: 28424911 DOI: 10.1007/s00464-017-5557-2.

Endoscopic submucosal dissection for gastric gastrointestinal stromal tumors: a retrospective cohort study.

An W, Sun P, Gao J, Jiang F, Liu F, Chen J Surg Endosc. 2017; 31(11):4522-4531.

PMID: 28374257 DOI: 10.1007/s00464-017-5511-3.

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