Brønsted Acid-catalyzed Efficient Strecker Reaction of Ketones, Amines and Trimethylsilyl Cyanide

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2010 Mar 6

PMID 20204214

Citations 3

Authors

Guang-Wu Zhang

Dong-Hua Zheng

Jing Nie

Teng Wang

Jun-An Ma

Affiliations

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Abstract

A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of alpha-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

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