Lingering Prenatal Effects of the 1918 Influenza Pandemic on Cardiovascular Disease

Overview

Journal J Dev Orig Health Dis

Publisher Cambridge University Press

Specialty Biology

Date 2010 Mar 4

PMID 20198106

Citations 72

Authors

B Mazumder

D Almond

K Park

E M Crimmins

C E Finch

Affiliations

Soon will be listed here.

Abstract

Prenatal exposure to the 1918 influenza pandemic (Influenza A, H1N1 subtype) is associated with ⩾20% excess cardiovascular disease at 60 to 82 years of age, relative to cohorts born without exposure to the influenza epidemic, either prenatally or postnatally (defined by the quarter of birth), in the 1982-1996 National Health Interview Surveys of the USA. Males showed stronger effects of influenza on increased later heart disease than females. Adult height at World War II enlistment was lower for the 1919 birth cohort than for those born in adjacent years, suggesting growth retardation. Calculations on the prevalence of maternal infections indicate that prenatal exposure to even uncomplicated maternal influenza may have lasting consequences later in life. These findings suggest novel roles for maternal infections in the fetal programming of cardiovascular risk factors that are independent of maternal malnutrition.

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References

Hampton T . Virulence of 1918 influenza virus linked to inflammatory innate immune response. JAMA. 2007; 297(6):580. DOI: 10.1001/jama.297.6.580. View

Yamashita T, Freigang S, Eberle C, Pattison J, Gupta S, Napoli C . Maternal immunization programs postnatal immune responses and reduces atherosclerosis in offspring. Circ Res. 2006; 99(7):e51-64. DOI: 10.1161/01.RES.0000244003.08127.cc. View

Engstad T, Bonaa K, Viitanen M . Validity of self-reported stroke : The Tromso Study. Stroke. 2000; 31(7):1602-7. DOI: 10.1161/01.str.31.7.1602. View

Rastogi D, Wang C, Mao X, Lendor C, Rothman P, Miller R . Antigen-specific immune responses to influenza vaccine in utero. J Clin Invest. 2007; 117(6):1637-46. PMC: 1878514. DOI: 10.1172/JCI29466. View

Luk J, Gross P, Thompson W . Observations on mortality during the 1918 influenza pandemic. Clin Infect Dis. 2001; 33(8):1375-8. DOI: 10.1086/322662. View

Napoli C, DArmiento F, Mancini F, Postiglione A, Witztum J, Palumbo G . Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest. 1998; 100(11):2680-90. PMC: 508471. DOI: 10.1172/JCI119813. View

Shi L, Tu N, Patterson P . Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus. Int J Dev Neurosci. 2005; 23(2-3):299-305. DOI: 10.1016/j.ijdevneu.2004.05.005. View

Acs N, Banhidy F, Puho E, Czeizel A . Pregnancy complications and delivery outcomes of pregnant women with influenza. J Matern Fetal Neonatal Med. 2006; 19(3):135-40. DOI: 10.1080/14767050500381180. View

Hoek H, Brown A, Susser E . The Dutch famine and schizophrenia spectrum disorders. Soc Psychiatry Psychiatr Epidemiol. 1998; 33(8):373-9. DOI: 10.1007/s001270050068. View

10.

Gluckman P, Hanson M, Beedle A, Raubenheimer D . Fetal and neonatal pathways to obesity. Front Horm Res. 2008; 36:61-72. DOI: 10.1159/000115337. View

11.

Heijmans B, Tobi E, Stein A, Putter H, Blauw G, Susser E . Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008; 105(44):17046-9. PMC: 2579375. DOI: 10.1073/pnas.0806560105. View

12.

Morens D, Taubenberger J, Fauci A . The persistent legacy of the 1918 influenza virus. N Engl J Med. 2009; 361(3):225-9. PMC: 2749954. DOI: 10.1056/NEJMp0904819. View

13.

Ortiz L, Quan A, Zarzar F, Weinberg A, Baum M . Prenatal dexamethasone programs hypertension and renal injury in the rat. Hypertension. 2003; 41(2):328-34. PMC: 4127977. DOI: 10.1161/01.hyp.0000049763.51269.51. View

14.

Painter R, de Rooij S, Bossuyt P, Simmers T, Osmond C, Barker D . Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am J Clin Nutr. 2006; 84(2):322-7. DOI: 10.1093/ajcn/84.1.322. View

15.

Heltzer M, Coffin S, Maurer K, Bagashev A, Zhang Z, Orange J . Immune dysregulation in severe influenza. J Leukoc Biol. 2009; 85(6):1036-43. PMC: 2698588. DOI: 10.1189/jlb.1108710. View

16.

Fatemi S, Folsom T, Reutiman T, Huang H, Oishi K, Mori S . Prenatal viral infection of mice at E16 causes changes in gene expression in hippocampi of the offspring. Eur Neuropsychopharmacol. 2009; 19(9):648-53. PMC: 2716397. DOI: 10.1016/j.euroneuro.2009.03.004. View

17.

Doblhammer G, Vaupel J . Lifespan depends on month of birth. Proc Natl Acad Sci U S A. 2001; 98(5):2934-9. PMC: 30243. DOI: 10.1073/pnas.041431898. View

18.

de Rooij S, Painter R, Roseboom T, Phillips D, Osmond C, Barker D . Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine. Diabetologia. 2006; 49(4):637-43. DOI: 10.1007/s00125-005-0136-9. View

19.

Barker D . The origins of the developmental origins theory. J Intern Med. 2007; 261(5):412-7. DOI: 10.1111/j.1365-2796.2007.01809.x. View

20.

Freeman D, BARNO A . Deaths from Asian influenza associated with pregnancy. Am J Obstet Gynecol. 1959; 78:1172-5. DOI: 10.1016/0002-9378(59)90570-8. View