CRY2 is Associated with Depression

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2010 Mar 3

PMID 20195522

Citations 66

Authors

Catharina Lavebratt

Louise K Sjoholm

Pia Soronen

Tiina Paunio

Marquis P Vawter

William E Bunney

Rolf Adolfsson

Yvonne Forsell

Joseph C Wu

John R Kelsoe

Timo Partonen

Martin Schalling

Affiliations

Soon will be listed here.

Abstract

Background: Abnormalities in the circadian clockwork often characterize patients with major depressive and bipolar disorders. Circadian clock genes are targets of interest in these patients. CRY2 is a circadian gene that participates in regulation of the evening oscillator. This is of interest in mood disorders where a lack of switch from evening to morning oscillators has been postulated.

Principal Findings: We observed a marked diurnal variation in human CRY2 mRNA levels from peripheral blood mononuclear cells and a significant up-regulation (P = 0.020) following one-night total sleep deprivation, a known antidepressant. In depressed bipolar patients, levels of CRY2 mRNA were decreased (P = 0.029) and a complete lack of increase was observed following sleep deprivation. To investigate a possible genetic contribution, we undertook SNP genotyping of the CRY2 gene in two independent population-based samples from Sweden (118 cases and 1011 controls) and Finland (86 cases and 1096 controls). The CRY2 gene was significantly associated with winter depression in both samples (haplotype analysis in Swedish and Finnish samples: OR = 1.8, P = 0.0059 and OR = 1.8, P = 0.00044, respectively).

Conclusions: We propose that a CRY2 locus is associated with vulnerability for depression, and that mechanisms of action involve dysregulation of CRY2 expression.

Citing Articles

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