Microbe-dendritic Cell Dialog Controls Regulatory T-cell Fate

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2010 Mar 3

PMID 20193027

Citations 20

Authors

John R Grainger

Jason A Hall

Nicolas Bouladoux

Guillaume Oldenhove

Yasmine Belkaid

Affiliations

Soon will be listed here.

Abstract

Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes.

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