Resistance to and Synthesis of the Antibiotic Mupirocin

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2010 Mar 2

PMID 20190824

Citations 67

Authors

Christopher M Thomas

Joanne Hothersall

Christine L Willis

Thomas J Simpson

Affiliations

Soon will be listed here.

Abstract

Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.

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