Identification of Functional Modules That Correlate with Phenotypic Difference: the Influence of Network Topology

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2010 Mar 2

PMID 20187943

Citations 45

Authors

Jui-Hung Hung

Troy W Whitfield

Tun-Hsiang Yang

Zhenjun Hu

Zhiping Weng

Charles DeLisi

Affiliations

Soon will be listed here.

Abstract

One of the important challenges to post-genomic biology is relating observed phenotypic alterations to the underlying collective alterations in genes. Current inferential methods, however, invariably omit large bodies of information on the relationships between genes. We present a method that takes account of such information - expressed in terms of the topology of a correlation network - and we apply the method in the context of current procedures for gene set enrichment analysis.

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