Protein Degradation, Aggregation, and Misfolding

Overview

Journal Mov Disord

Date 2010 Feb 27

PMID 20187257

Citations 44

Authors

Ana Maria Cuervo

Esther S P Wong

Marta Martinez-Vicente

Affiliations

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Abstract

The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease.

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