The Influence of Temporal Resolution in Determining Pharmacokinetic Parameters from DCE-MRI Data

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2010 Feb 27

PMID 20187187

Citations 31

Authors

Marieke Heisen

Xiaobing Fan

Johannes Buurman

Natal A W Van Riel

Gregory S Karczmar

Bart M Ter Haar Romeny

Affiliations

Soon will be listed here.

Abstract

We investigated the influence of the temporal resolution of dynamic contrast-enhanced MRI data on pharmacokinetic parameter estimation. Dynamic Gd-DTPA (Gadolinium-diethylene triamine pentaacetic acid) enhanced MRI data of implanted prostate tumors on rat hind limb were acquired at 4.7 T, with a temporal resolution of approximately 5 sec. The data were subsequently downsampled to temporal resolutions in the range of 15 sec to 85 sec, using a strategy that involves a recombination of k-space data. A basic two-compartment model was fit to the contrast agent uptake curves. The results demonstrated that as temporal resolution decreases, the volume transfer constant (K(trans)) is progressively underestimated (approximately 4% to approximately 25%), and the fractional extravascular extracellular space (v(e)) is progressively overestimated (approximately 1% to approximately 10%). The proposed downsampling strategy simulates the influence of temporal resolution more realistically than simply downsampling by removing samples.

Citing Articles

Deconvolution-Based Pharmacokinetic Analysis to Improve the Prediction of Pathological Information of Breast Cancer.

Zhang L, Fan M, Li L J Imaging Inform Med. 2024; 37(1):13-24.

PMID: 38343210 PMC: 10976965. DOI: 10.1007/s10278-023-00915-9.

Focal nodular enhancement on DCE MRI of the prostatectomy bed: radiologic-pathologic correlations and prognostic value.

Park M, Park K, Kim M, Kim J Eur Radiol. 2022; 33(4):2985-2994.

PMID: 36350389 DOI: 10.1007/s00330-022-09241-0.

Determination of hepatic extraction fraction with gadoxetate low-temporal resolution DCE-MRI-based deconvolution analysis: validation with ALBI score and Child-Pugh class.

Phonlakrai M, Ramadan S, Simpson J, Gholizadeh N, Arm J, Skehan K J Med Radiat Sci. 2022; 70 Suppl 2:48-58.

PMID: 36088635 PMC: 10122932. DOI: 10.1002/jmrs.617.

The Influence of Data-Driven Compressed Sensing Reconstruction on Quantitative Pharmacokinetic Analysis in Breast DCE MRI.

Wang P, Velikina J, Bancroft L, Samsonov A, Kelcz F, Strigel R Tomography. 2022; 8(3):1552-1569.

PMID: 35736876 PMC: 9227412. DOI: 10.3390/tomography8030128.

An in silico validation framework for quantitative DCE-MRI techniques based on a dynamic digital phantom.

Wu C, Hormuth 2nd D, Easley T, Eijkhout V, Pineda F, Karczmar G Med Image Anal. 2021; 73:102186.

PMID: 34329903 PMC: 8453106. DOI: 10.1016/j.media.2021.102186.

References

Marzola P, Mocchegiani E, Nicolato E, Tibaldi A, Sbarbati A, Osculati F . Chemical shift imaging at 4.7 tesla of thymus in young and old mice. J Magn Reson Imaging. 1999; 10(1):97-101. DOI: 10.1002/(sici)1522-2586(199907)10:1<97::aid-jmri14>3.0.co;2-y. View

Cheng H . Investigation and optimization of parameter accuracy in dynamic contrast-enhanced MRI. J Magn Reson Imaging. 2008; 28(3):736-43. DOI: 10.1002/jmri.21489. View

Aref M, Handbury J, Ji J, Aref S, Wiener E . Spatial and temporal resolution effects on dynamic contrast-enhanced magnetic resonance mammography. Magn Reson Imaging. 2007; 25(1):14-34. DOI: 10.1016/j.mri.2006.09.025. View

Aerts H, van Riel N, Backes W . System identification theory in pharmacokinetic modeling of dynamic contrast-enhanced MRI: influence of contrast injection. Magn Reson Med. 2008; 59(5):1111-9. DOI: 10.1002/mrm.21575. View

Buckley D . Uncertainty in the analysis of tracer kinetics using dynamic contrast-enhanced T1-weighted MRI. Magn Reson Med. 2002; 47(3):601-6. DOI: 10.1002/mrm.10080. View

Mann R, Kuhl C, Kinkel K, Boetes C . Breast MRI: guidelines from the European Society of Breast Imaging. Eur Radiol. 2008; 18(7):1307-18. PMC: 2441490. DOI: 10.1007/s00330-008-0863-7. View

Henderson E, Rutt B, Lee T . Temporal sampling requirements for the tracer kinetics modeling of breast disease. Magn Reson Imaging. 1998; 16(9):1057-73. DOI: 10.1016/s0730-725x(98)00130-1. View

Gal Y, Mehnert A, Bradley A, McMahon K, Crozier S . An evaluation of four parametric models of contrast enhancement for dynamic magnetic resonance imaging of the breast. Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:71-4. DOI: 10.1109/IEMBS.2007.4352225. View

Harrer J, Parker G, Haroon H, Buckley D, Embelton K, Roberts C . Comparative study of methods for determining vascular permeability and blood volume in human gliomas. J Magn Reson Imaging. 2004; 20(5):748-57. DOI: 10.1002/jmri.20182. View

10.

Furman-Haran E, Margalit R, Grobgeld D, Degani H . Dynamic contrast-enhanced magnetic resonance imaging reveals stress-induced angiogenesis in MCF7 human breast tumors. Proc Natl Acad Sci U S A. 1996; 93(13):6247-51. PMC: 39007. DOI: 10.1073/pnas.93.13.6247. View

11.

Kuhl C, Schild H, Morakkabati N . Dynamic bilateral contrast-enhanced MR imaging of the breast: trade-off between spatial and temporal resolution. Radiology. 2005; 236(3):789-800. DOI: 10.1148/radiol.2363040811. View

12.

Fan X, Medved M, River J, Zamora M, Corot C, Robert P . New model for analysis of dynamic contrast-enhanced MRI data distinguishes metastatic from nonmetastatic transplanted rodent prostate tumors. Magn Reson Med. 2004; 51(3):487-94. DOI: 10.1002/mrm.10737. View

13.

Kovar D, Lewis M, Karczmar G . A new method for imaging perfusion and contrast extraction fraction: input functions derived from reference tissues. J Magn Reson Imaging. 1998; 8(5):1126-34. DOI: 10.1002/jmri.1880080519. View

14.

Medved M, Karczmar G, Yang C, Dignam J, Gajewski T, Kindler H . Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time. J Magn Reson Imaging. 2004; 20(1):122-8. DOI: 10.1002/jmri.20061. View

15.

Tofts P, Brix G, Buckley D, Evelhoch J, Henderson E, Knopp M . Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999; 10(3):223-32. DOI: 10.1002/(sici)1522-2586(199909)10:3<223::aid-jmri2>3.0.co;2-s. View

16.

Ramirez M, Ragan D, Kundra V, Bankson J . Feasibility of multiple-mouse dynamic contrast-enhanced MRI. Magn Reson Med. 2007; 58(3):610-5. DOI: 10.1002/mrm.21348. View