Simian Varicella Virus Pathogenesis

Overview

Journal Curr Top Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2010 Feb 27

PMID 20186611

Citations 21

Authors

Ravi Mahalingam

Ilhem Messaoudi

Don Gilden

Affiliations

Soon will be listed here.

Abstract

Because varicella zoster virus (VZV) is an exclusively human pathogen, the development of an animal model is necessary to study pathogenesis, latency, and reactivation. The pathological, virological, and immunological features of simian varicella virus (SVV) infection in nonhuman primates are similar to those of VZV infection in humans. Both natural infection of cynomolgus and African green monkeys as well as intrabronchial inoculation of rhesus macaques with SVV provide the most useful models to study viral and immunological aspects of latency and the host immune response. Experimental immunosuppression of monkeys latently infected with SVV results in zoster, thus providing a new model system to study how the loss of adaptive immunity modulates virus reactivation.

Citing Articles

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Meningitis/meningoencephalitis caused by varicella zoster virus reactivation: a retrospective single-center case series study.

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Distinct transcriptional responses to fatal Ebola virus infection in cynomolgus and rhesus macaques suggest species-specific immune responses.

Pinski A, Maroney K, Marzi A, Messaoudi I Emerg Microbes Infect. 2021; 10(1):1320-1330.

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