Cortical Plasticity Induced by Inhibitory Neuron Transplantation

Overview

Journal Science

Specialty Science

Date 2010 Feb 27

PMID 20185728

Citations 152

Authors

Derek G Southwell

Robert C Froemke

Arturo Alvarez-Buylla

Michael P Stryker

Sunil P Gandhi

Affiliations

Soon will be listed here.

Abstract

Critical periods are times of pronounced brain plasticity. During a critical period in the postnatal development of the visual cortex, the occlusion of one eye triggers a rapid reorganization of neuronal responses, a process known as ocular dominance plasticity. We have shown that the transplantation of inhibitory neurons induces ocular dominance plasticity after the critical period. Transplanted inhibitory neurons receive excitatory synapses, make inhibitory synapses onto host cortical neurons, and promote plasticity when they reach a cellular age equivalent to that of endogenous inhibitory neurons during the normal critical period. These findings suggest that ocular dominance plasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons. By inducing plasticity, inhibitory neuron transplantation may facilitate brain repair.

Citing Articles

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