Prevention of Torsade De Pointes in Hospital Settings: a Scientific Statement from the American Heart Association and the American College of Cardiology Foundation

Overview

Journal J Am Coll Cardiol

Specialty Cardiology & Vascular Diseases

Date 2010 Feb 27

PMID 20185054

Citations 147

Authors

Barbara J Drew

Michael J Ackerman

Marjorie Funk

W Brian Gibler

Paul Kligfield

Venu Menon

George J Philippides

Dan M Roden

Wojciech Zareba

Affiliations

Soon will be listed here.

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References

Abbott G, Sesti F, Splawski I, Buck M, Lehmann M, Timothy K . MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999; 97(2):175-87. DOI: 10.1016/s0092-8674(00)80728-x. View

Drici M, Knollmann B, Wang W, Woosley R . Cardiac actions of erythromycin: influence of female sex. JAMA. 1998; 280(20):1774-6. DOI: 10.1001/jama.280.20.1774. View

Sloth Pedersen H, Elming H, Seibaek M, Burchardt H, Brendorp B, Torp-Pedersen C . Risk factors and predictors of Torsade de pointes ventricular tachycardia in patients with left ventricular systolic dysfunction receiving Dofetilide. Am J Cardiol. 2007; 100(5):876-80. DOI: 10.1016/j.amjcard.2007.04.020. View

Napolitano C, Schwartz P, Brown A, Ronchetti E, Bianchi L, Pinnavaia A . Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias. J Cardiovasc Electrophysiol. 2000; 11(6):691-6. DOI: 10.1111/j.1540-8167.2000.tb00033.x. View

Roden D . Long QT syndrome: reduced repolarization reserve and the genetic link. J Intern Med. 2005; 259(1):59-69. DOI: 10.1111/j.1365-2796.2005.01589.x. View

Choy A, Lang C, Chomsky D, Rayos G, Wilson J, Roden D . Normalization of acquired QT prolongation in humans by intravenous potassium. Circulation. 1997; 96(7):2149-54. DOI: 10.1161/01.cir.96.7.2149. View

Pinski S, Eguia L, Trohman R . What is the minimal pacing rate that prevents torsades de pointes? Insights from patients with permanent pacemakers. Pacing Clin Electrophysiol. 2002; 25(11):1612-5. DOI: 10.1046/j.1460-9592.2002.01612.x. View

Paulussen A, Gilissen R, Armstrong M, Doevendans P, Verhasselt P, Smeets H . Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients. J Mol Med (Berl). 2004; 82(3):182-8. DOI: 10.1007/s00109-003-0522-z. View

White C, Xie J, Chow M, Kluger J . Prophylactic magnesium to decrease the arrhythmogenic potential of class III antiarrhythmic agents in a rabbit model. Pharmacotherapy. 1999; 19(5):635-40. DOI: 10.1592/phco.19.8.635.31528. View

10.

Chung K, Wang Y, Liu B, Supernaw R . Management of ventricular dysrhythmia secondary to trazodone overdose. J Emerg Med. 2007; 35(2):171-4. DOI: 10.1016/j.jemermed.2007.02.036. View

11.

Plant L, Bowers P, Liu Q, Morgan T, Zhang T, State M . A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. J Clin Invest. 2006; 116(2):430-5. PMC: 1359045. DOI: 10.1172/JCI25618. View

12.

Zeltser D, Justo D, Halkin A, Prokhorov V, Heller K, Viskin S . Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors. Medicine (Baltimore). 2003; 82(4):282-90. DOI: 10.1097/01.md.0000085057.63483.9b. View

13.

Singh B . Safety profile of bepridil determined from clinical trials in chronic stable angina in the United States. Am J Cardiol. 1992; 69(11):68D-74D. DOI: 10.1016/0002-9149(92)90962-x. View

14.

Lehtonen A, Fodstad H, Laitinen-Forsblom P, Toivonen L, Kontula K, Swan H . Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes. Heart Rhythm. 2007; 4(5):603-7. DOI: 10.1016/j.hrthm.2007.01.019. View

15.

De Bruin M, Langendijk P, Koopmans R, Wilde A, Leufkens H, Hoes A . In-hospital cardiac arrest is associated with use of non-antiarrhythmic QTc-prolonging drugs. Br J Clin Pharmacol. 2006; 63(2):216-23. PMC: 2000578. DOI: 10.1111/j.1365-2125.2006.02722.x. View

16.

Justo D, Prokhorov V, Heller K, Zeltser D . Torsade de pointes induced by psychotropic drugs and the prevalence of its risk factors. Acta Psychiatr Scand. 2005; 111(3):171-6. DOI: 10.1111/j.1600-0447.2004.00469.x. View

17.

Roden D, Viswanathan P . Genetics of acquired long QT syndrome. J Clin Invest. 2005; 115(8):2025-32. PMC: 1180553. DOI: 10.1172/JCI25539. View

18.

Yang T, Roden D . Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence. Circulation. 1996; 93(3):407-11. DOI: 10.1161/01.cir.93.3.407. View

19.

Helfenbein E, Zhou S, Lindauer J, Field D, Gregg R, Wang J . An algorithm for continuous real-time QT interval monitoring. J Electrocardiol. 2006; 39(4 Suppl):S123-7. DOI: 10.1016/j.jelectrocard.2006.05.018. View

20.

Roden D, Iansmith D . Effects of low potassium or magnesium concentrations on isolated cardiac tissue. Am J Med. 1987; 82(3A):18-23. DOI: 10.1016/0002-9343(87)90128-8. View