Nav2 is Necessary for Cranial Nerve Development and Blood Pressure Regulation

Overview

Journal Neural Dev

Publisher Biomed Central

Specialty Neurology

Date 2010 Feb 27

PMID 20184720

Citations 30

Authors

Elizabeth M McNeill

Kenneth P Roos

Dieder Moechars

Margaret Clagett-Dame

Affiliations

Soon will be listed here.

Abstract

Background: All-trans retinoic acid (atRA) is required for nervous system development, including the developing hindbrain region. Neuron navigator 2 (Nav2) was first identified as an atRA-responsive gene in human neuroblastoma cells (retinoic acid-induced in neuroblastoma 1, Rainb1), and is required for atRA-mediated neurite outgrowth. In this paper, we explore the importance of Nav2 in nervous system development and function in vivo.

Results: Nav2 hypomorphic homozygous mutants show decreased survival starting at birth. Nav2 mutant embryos show an overall reduction in nerve fiber density, as well as specific defects in cranial nerves IX (glossopharyngeal) and X (vagus). Nav2 hypomorphic mutant adult mice also display a blunted baroreceptor response compared to wild-type controls.

Conclusions: Nav2 functions in mammalian nervous system development, and is required for normal cranial nerve development and blood pressure regulation in the adult.

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