Human Neuroblastoma Cell Lines As Models for the in Vitro Study of Neoplastic and Neuronal Cell Differentiation

Overview

Journal Environ Health Perspect

Date 1989 Mar 1

PMID 2538324

Citations 47

Authors

E Abemayor

N Sidell

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma is a childhood solid tumor composed of primitive cells derived from precursors of the autonomic nervous system. This neoplasm has the highest rate of spontaneous regression of all cancer types and has been noted to undergo spontaneous and chemically induced differentiation into elements resembling mature nervous tissue. As such, neuroblastoma has been a prime model system for the study of neuronal differentiation and the process of cancer cell maturation. In this paper we review those agents that have been described to induce the differentiation of neuroblastoma, with an emphasis on the effects and possible mechanisms of action of a group of related compounds, the retinoids. With this model system and the availability of subclones that are both responsive and resistant to chemically induced differentiation, fundamental questions regarding the mechanisms and processes underlying cell maturation have become more amenable to in vitro study.

Citing Articles

Perspective on Similarities and Possible Overlaps of Congenital Disease Formation-Exemplified on a Case of Congenital Diaphragmatic Hernia and Neuroblastoma in a Neonate.

Huo Z, Bilang R, Brantner B, von der Weid N, Holland-Cunz S, Gros S Children (Basel). 2021; 8(2).

PMID: 33671521 PMC: 7926624. DOI: 10.3390/children8020163.

AQP1-Driven Migration Is Independent of Other Known Adverse Factors but Requires a Hypoxic Undifferentiated Cell Profile in Neuroblastoma.

Pini N, Huo Z, Kym U, Holland-Cunz S, Gros S Children (Basel). 2021; 8(1).

PMID: 33467498 PMC: 7829990. DOI: 10.3390/children8010048.

Aspirin inhibits proliferation and promotes differentiation of neuroblastoma cells via p21 protein up-regulation and Rb1 pathway modulation.

Pozzoli G, Petrucci G, Navarra P, Marei H, Cenciarelli C J Cell Mol Med. 2019; 23(10):7078-7087.

PMID: 31429199 PMC: 6787451. DOI: 10.1111/jcmm.14610.

Somatostatin-Mediated Changes in Microtubule-Associated Proteins and Retinoic Acid-Induced Neurite Outgrowth in SH-SY5Y Cells.

Paik S, Somvanshi R, Kumar U J Mol Neurosci. 2019; 68(1):120-134.

PMID: 30879180 DOI: 10.1007/s12031-019-01291-2.

MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines.

Aygun N, Altungoz O Mol Med Rep. 2018; 19(1):345-361.

PMID: 30483774 PMC: 6297758. DOI: 10.3892/mmr.2018.9686.

References

Hsie A, PUCK T . Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone. Proc Natl Acad Sci U S A. 1971; 68(2):358-61. PMC: 388937. DOI: 10.1073/pnas.68.2.358. View

Hamill O, Marty A, Neher E, Sakmann B, Sigworth F . Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 1981; 391(2):85-100. DOI: 10.1007/BF00656997. View

Haussler M, Donaldson C, Kelly M, Mangelsdorf D, Bowden G, Meinke W . Identification and quantitation of intracellular retinol and retinoic acid binding proteins in cultured cells. Biochim Biophys Acta. 1984; 803(1-2):54-62. DOI: 10.1016/0167-4889(84)90054-5. View

Brodeur G, Seeger R, Schwab M, Varmus H, Bishop J . Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science. 1984; 224(4653):1121-4. DOI: 10.1126/science.6719137. View

Helson L . Investigational chemotherapy of neuroblastoma. J Fla Med Assoc. 1979; 66(3):284-7. View

Faletto D, Arrow A, Macara I . An early decrease in phosphatidylinositol turnover occurs on induction of Friend cell differentiation and precedes the decrease in c-myc expression. Cell. 1985; 43(1):315-25. DOI: 10.1016/0092-8674(85)90037-6. View

Grady E, Schwab M, Rosenau W . Expression of N-myc and c-src during the development of fetal human brain. Cancer Res. 1987; 47(11):2931-6. View

Weston J . The migration and differentiation of neural crest cells. Adv Morphog. 1970; 8:41-114. DOI: 10.1016/b978-0-12-028608-9.50006-5. View

Reed J, England D . The effect of nerve growth factor on the development of sodium channels in PC12 cells. Biochem Cell Biol. 1986; 64(11):1153-9. DOI: 10.1139/o86-152. View

10.

Coggeshall K, Cambier J . B cell activation. VI. Effects of exogenous diglyceride and modulators of phospholipid metabolism suggest a central role for diacylglycerol generation in transmembrane signaling by mIg. J Immunol. 1985; 134(1):101-7. View

11.

Pahlman S, Odelstad L, Larsson E, Grotte G, Nilsson K . Phenotypic changes of human neuroblastoma cells in culture induced by 12-O-tetradecanoyl-phorbol-13-acetate. Int J Cancer. 1981; 28(5):583-9. DOI: 10.1002/ijc.2910280509. View

12.

Rowinsky E, Ettinger D, McGuire W, Noe D, Grochow L, Donehower R . Prolonged infusion of hexamethylene bisacetamide: a phase I and pharmacological study. Cancer Res. 1987; 47(21):5788-95. View

13.

Nau M, Brooks Jr B, Carney D, Gazdar A, Battey J, Sausville E . Human small-cell lung cancers show amplification and expression of the N-myc gene. Proc Natl Acad Sci U S A. 1986; 83(4):1092-6. PMC: 323017. DOI: 10.1073/pnas.83.4.1092. View

14.

West G, Uki J, Herschman H, Seeger R . Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore. Cancer Res. 1977; 37(5):1372-6. View

15.

Amatruda 3rd T, Sidell N, Ranyard J, Koeffler H . Retinoic acid treatment of human neuroblastoma cells is associated with decreased N-myc expression. Biochem Biophys Res Commun. 1985; 126(3):1189-95. DOI: 10.1016/0006-291x(85)90311-0. View

16.

Slamon D, Boone T, Seeger R, Keith D, Chazin V, Lee H . Identification and characterization of the protein encoded by the human N-myc oncogene. Science. 1986; 232(4751):768-72. DOI: 10.1126/science.3008339. View

17.

Wang S, Gudas L . Selection and characterization of F9 teratocarcinoma stem cell mutants with altered responses to retinoic acid. J Biol Chem. 1984; 259(9):5899-906. View

18.

Prasad K . X-ray-induced morphological differentiation of mouse neuroblastoma cells in vitro. Nature. 1971; 234(5330):471-3. DOI: 10.1038/234471a0. View

19.

Imashuku S, Sugano T, Fujiwara K, Todo S, Ogita S, Goto Y . Intra-aortic prostaglandin E1 infusion in maturation of neuroblastoma. Experientia. 1982; 38(8):932-3. DOI: 10.1007/BF01953660. View

20.

Okazaki T, Mochizuki T, Tashima M, Sawada H, Uchino H . Role of intracellular calcium ion in human promyelocytic leukemia HL-60 cell differentiation. Cancer Res. 1986; 46(12 Pt 1):6059-63. View