Serum Vitamin D Concentrations in Hospitalized Critically Ill Dogs

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Mar 29

PMID 29590167

Citations 13

Authors

Jared A Jaffey

Robert C Backus

Kaylyn M McDaniel

Amy E DeClue

Affiliations

Soon will be listed here.

Abstract

Hypovitaminosis D has been extensively documented in critically ill humans. However, whether or not critically ill dogs have alterations in vitamin D concentrations remains unconfirmed. The primary aims of our study were to compare serum 25-hydroxycholecalciferol [25(OH)D] concentrations in critically ill dogs with healthy control dogs, determine the prognostic utility of serum 25(OH)D concentration as a biomarker in critically ill dogs, and to assess if serum 25(OH)D concentrations in critically ill dogs are associated with length of stay in the intensive care unit or illness severity. Serum concentrations of 25(OH)D together with a range of other clinical, biochemical, and hematological parameters, were measured in 99 dogs within 24 hours of admission to the Intensive Care Unit (ICU). Critically ill dogs (P = 0.001) and dogs with sepsis (P = 0.002) had significantly lower serum 25(OH)D concentrations compared to healthy control dogs. In addition, serum 25(OH)D concentration was an independent predictor of in-hospital and 30 day survival. Using a cut-off of 33 ng/mL, serum 25(OH)D concentrations had excellent sensitivity (0.94; 95% CI, 0.71-1.00), but poor specificity (0.41; 95% CI, 0.31-0.53) for detection of survival. Serum 25(OH)D concentrations were inversely associated with acute patient physiologic and laboratory evaluation (APPLE) fast score but were not associated with ICU length of stay. Hospitalized dogs with critical illness have decreased serum 25(OH)D concentrations compared to healthy dogs and can be used to predict survival in this cohort.

Citing Articles

Longitudinal Evaluation of Vitamin D, Parathyroid Hormone, Antimicrobial Peptides, and Immunomodulatory Genes in Hospitalized Foals.

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PMID: 40008921 PMC: 11863360. DOI: 10.1111/jvim.70012.

Dysregulated serum concentrations of fat-soluble vitamins in dogs with chronic enteropathy.

Serafini F, Maxwell K, Zhu X, Lennon E J Vet Intern Med. 2024; 38(5):2612-2619.

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Efficacy of vitamin D in maintaining serum total vitamin D concentrations and bone mineralisation in adult dogs fed a plant-based (vegan) diet in a 3-month randomised trial.

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Evaluation of serum 25-hydroxyvitamin D, C-reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis.

Hernandez B, Jaffey J, Cohn L, Backus R, KuKanich K, Hanzlicek A J Vet Intern Med. 2023; 37(2):476-483.

PMID: 36748822 PMC: 10061178. DOI: 10.1111/jvim.16640.

Serum 25-hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease.

Jaffey J, Kreisler R, Shubitz L, Backus R, Hostnik E, Wycislo K J Vet Intern Med. 2023; 37(1):150-160.

PMID: 36629803 PMC: 9889719. DOI: 10.1111/jvim.16629.

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