Is Daily 400 IU of Vitamin D Supplementation Appropriate for Every Country: a Cross-sectional Study

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2010 Feb 20

PMID 20169351

Citations 7

Authors

Hasan Onal

Erdal Adal

Secil Alpaslan

Atilla Ersen

Ahmet Aydin

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D deficiency in childhood is a significant problem worldwide. Religious, social customs, and lack of food fortification were significant hurdles in the way of the rickets scourge. Recent data support a serum level of 25(OH)D level > 40 ng/mL as the appropriate standard to achieve to prevent rickets. Herein, the current approaches of preventing rickets and optimal level of different vitamin D intakes were evaluated.

Methods: A total of 148 fully breastfed, healthy children between age of 2-24 months were investigated by screening serum 25(OH)D from April 1 to May 31, 2006. Three groups were composed according to ages (2-6, 6-12, 12-24 months), and those groups were paired with three subgroups established according to vitamin D intake of ≤300, 400, and 600 IU/day. Vitamin D status was evaluated with regard to cut-off value of 15 ng/mL and 40 mg/dL. The clothing types and vitamin D supplementation of mothers were recorded.

Results: We found that 27.3% of cases in 2-6 months, 8.3% in 6-12 months and 30% in 12-24 months had 25(OH)D <15 ng/mL and 54.5, 33.3, and 50% of cases were <40 ng/dL with 400 IU/day vitamin D intake. With 600 IU/day supplementation, 14.3, 10.3, and 4.8% of cases had 25(OH)D <15 ng/mL, respectively.

Conclusion: Vitamin D intake of 400 IU/day seems to be favorable at the first year in breastfed children but vitamin D deficiency was still evident after prophylaxis. Vitamin D supplementation should be at least 600 IU/day in Turkey, and nutrition policy should focus on the food fortification with vitamin D.

Citing Articles

Different Vitamin D Supplementation Strategies in the First Years of Life: A Systematic Review.

Corsello A, Milani G, Gianni M, Dipasquale V, Romano C, Agostoni C Healthcare (Basel). 2022; 10(6).

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Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.

Tan M, Abrams S, Osborn D Cochrane Database Syst Rev. 2020; 12:CD013046.

PMID: 33305822 PMC: 8812278. DOI: 10.1002/14651858.CD013046.pub2.

Serum 25 hydroxyvitamin D status in 6-month-old infants in Guangzhou, China: A paired longitudinal follow up study.

Wang J, Zhang J, Wei R, Hu S, Lin T, Lash G Matern Child Nutr. 2020; 16(2):e12924.

PMID: 31970860 PMC: 7083469. DOI: 10.1111/mcn.12924.

Factors Influencing Serum Vitamin D Concentration in Turkish Children Residing in İzmir: A Single-Center Experience.

Gulez P, Korkmaz H, Ozkok D, Can D, Ozkan B J Clin Res Pediatr Endocrinol. 2016; 7(4):294-300.

PMID: 26777040 PMC: 4805218. DOI: 10.4274/jcrpe.1938.

Comparison of two regimens of vitamin D supplementation for vitamin D-deficient neonates.

Shakiba M, Pahloosye A, Mirouliaei M, Islami Z Singapore Med J. 2014; 55(5):266-70.

PMID: 24862751 PMC: 4291984. DOI: 10.11622/smedj.2014070.

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