The Antiplasmodial Agents of the Stem Bark of Entandrophragma Angolense (Meliaceae)

Overview

Journal Afr J Tradit Complement Altern Med

Specialty Rehabilitation Medicine

Date 2010 Feb 18

PMID 20162084

Citations 8

Authors

Jean Bickii

Guy Raymond Feuya Tchouya

Jean Claude Tchouankeu

Etienne Tsamo

Affiliations

Soon will be listed here.

Abstract

In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane-methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7alpha-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC(50)s of 2 and 5.4 microg/ml respectively. Other compounds were moderately active.

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References

Weenen H, Nkunya M, Bray D, Mwasumbi L, Kinabo L, Kilimali V . Antimalarial compounds containing an alpha,beta-unsaturated carbonyl moiety from Tanzanian medicinal plants. Planta Med. 1990; 56(4):371-3. DOI: 10.1055/s-2006-960985. View

Phillipson J, Wright C . Antiprotozoal agents from plant sources. Planta Med. 1991; 57(7 Suppl):S53-9. DOI: 10.1055/s-2006-960230. View

Noster S, Kraus L . In vitro antimalarial activity of Coutarea latiflora and Exostema caribaeum extracts on Plasmodium falciparum. Planta Med. 1990; 56(1):63-5. DOI: 10.1055/s-2006-960885. View

ONeill M, Bray D, Boardman P, Phillipson J, Warhurst D, Peters W . Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids. Antimicrob Agents Chemother. 1986; 30(1):101-4. PMC: 176444. DOI: 10.1128/AAC.30.1.101. View

Lambros C, Vanderberg J . Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol. 1979; 65(3):418-20. View

Obih P, Makinde M, Laoye O . Investigations of various extracts of Morinda lucida for antimalarial actions on Plasmodium berghei berghei in mice. Afr J Med Med Sci. 1985; 14(1-2):45-9. View

Nkunya M, Weenen H, Bray D, Mgani Q, Mwasumbi L . Antimalarial activity of Tanzanian plants and their active constituents: the genus Uvaria. Planta Med. 1991; 57(4):341-3. DOI: 10.1055/s-2006-960113. View

Bickii J, Njifutie N, Foyere J, Basco L, Ringwald P . In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae). J Ethnopharmacol. 2000; 69(1):27-33. DOI: 10.1016/s0378-8741(99)00117-8. View

Koumaglo K, Gbeassor M, Nikabu O, de Souza C, Werner W . Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum. Planta Med. 1992; 58(6):533-4. DOI: 10.1055/s-2006-961543. View

10.

Weenen H, Nkunya M, Bray D, Mwasumbi L, Kinabo L, Kilimali V . Antimalarial activity of Tanzanian medicinal plants. Planta Med. 1990; 56(4):368-70. DOI: 10.1055/s-2006-960984. View

11.

Singh A, Rosenthal P . Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum. Antimicrob Agents Chemother. 2001; 45(3):949-51. PMC: 90401. DOI: 10.1128/AAC.45.3.949-951.2001. View

12.

Ferreira J, Floriani A, Filho V, Delle Monache F, Yunes R, Calixto J . Antinociceptive properties of the methanolic extract and two triterpenes isolated from Epidendrum Mosenii stems (Orchidaceae). Life Sci. 2000; 66(9):791-802. DOI: 10.1016/s0024-3205(99)00652-9. View