The BCL-2 Family Reunion

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2010 Feb 18

PMID 20159550

Citations 704

Authors

Jerry E Chipuk

Tudor Moldoveanu

Fabien Llambi

Melissa J Parsons

Douglas R Green

Affiliations

Soon will be listed here.

Abstract

B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.

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