Molecular Mechanisms of Green Tea Polyphenols

Overview

Journal Nutr Cancer

Publisher Routledge

Specialties Nutritional Sciences
Oncology

Date 2010 Feb 16

PMID 20155623

Citations 17

Authors

Q Ping Dou

Affiliations

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Abstract

Tea, next to water, is the most popular beverage in the world. It has been suggested that tea consumption has the cancer-preventive effects. Epidemiological studies have indicated decreased cancer occurrence in people who regularly drink green tea. Research has also discovered numerous mechanisms of action to explain the biological effects of tea. The most abundant and popular compound studied in tea research is (-)-epigallocatechin-3-gallate or (-)-EGCG, which is a powerful antioxidant and can inhibit a number of tumor cell proliferation and survival pathways. Tea polyphenols are known to inhibit metaloproteonases, various protein kinases, and proteins that regulate DNA replication and transformation. We also reported that ester bond-containing tea polyphenols, for example, (-)-EGCG, potently and specifically inhibited the tumor proteasomal activity. We further demonstrated that methylation on green tea polyphenols under physiological conditions decreased their proteasome-inhibitory activity, contributing to decreased cancer-preventive effects of tea consumption. Since (-)-EGCG is unstable under physiological conditions, we also developed the peracetate-protected or prodrug form of (-)-EGCG, Pro-EGCG (1), and showed that Pro-EGCG (1) increases the bioavailability, stability, and proteasome-inhibitory and anticancer activities of (-)-EGCG in human breast cancer cells and tumors, demonstrating its potential use for cancer prevention and treatment.

Citing Articles

Epigallocatechin-3-gallate-induced vascular normalization in A549-cell xenograft-bearing nude mice: therapeutic efficacy in combination with chemotherapy.

Deng P, Hu C, Xiong Z, Li Y, Jiang J, Yang H Cancer Manag Res. 2019; 11:2425-2439.

PMID: 30988640 PMC: 6441461. DOI: 10.2147/CMAR.S187750.

Coffee or Tea? A prospective cohort study on the associations of coffee and tea intake with overall and cause-specific mortality in men versus women.

van den Brandt P Eur J Epidemiol. 2018; 33(2):183-200.

PMID: 29380105 PMC: 5871637. DOI: 10.1007/s10654-018-0359-y.

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression.

Ratovitski E Curr Genomics. 2017; 18(2):175-205.

PMID: 28367075 PMC: 5345332. DOI: 10.2174/1389202917666160803165229.

Therapeutic properties of green tea against environmental insults.

Chen L, Mo H, Zhao L, Gao W, Wang S, Cromie M J Nutr Biochem. 2016; 40:1-13.

PMID: 27723473 PMC: 5124528. DOI: 10.1016/j.jnutbio.2016.05.005.

Y-27632 Increases Sensitivity of PANC-1 Cells to EGCG in Regulating Cell Proliferation and Migration.

Liu X, Bi Y Med Sci Monit. 2016; 22:3529-3534.

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