Regulation of IL-9 Expression by IL-25 Signaling

Overview

Journal Nat Immunol

Date 2010 Feb 16

PMID 20154671

Citations 107

Authors

Pornpimon Angkasekwinai

Seon Hee Chang

Manoj Thapa

Hiroshi Watarai

Chen Dong

Affiliations

Soon will be listed here.

Abstract

The physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of transforming growth factor-beta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25. Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral overexpression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression.

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