Plasma Proinsulin, C-peptide and Insulin in Diagnostic Suppression Tests for Insulinomas

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1977 Dec 1

PMID 201531

Citations 15

Authors

R C Turner

L G Heding

Affiliations

Soon will be listed here.

Citing Articles

Differentiation of insulin secretion patterns in insulinoma.

Saddig C, Goretzki P, Starke A World J Surg. 2008; 32(5):918-29.

PMID: 18259806 DOI: 10.1007/s00268-007-9450-3.

Human Insulinomas: Clinical, Cellular, and Molecular Aspects.

Komminoth P, Heitz P, Roth J Endocr Pathol. 2002; 10(4):269-281.

PMID: 12114763 DOI: 10.1007/BF02739769.

Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia.

Aynsley-Green A, Polak J, Bloom S, GOUGH M, Keeling J, Ashcroft S Arch Dis Child. 1981; 56(7):496-508.

PMID: 7023389 PMC: 1627357. DOI: 10.1136/adc.56.7.496.

Hypersecretion of proinsulin in thyrotoxicosis.

Sestoft L, Heding L Diabetologia. 1981; 21(2):103-7.

PMID: 7021283 DOI: 10.1007/BF00251275.

[Diagnosis and surgery of an insulinoma using a glucose-controlled insulin infusion system].

Muller-Esch G, Valesky A, Weber U, Wood G Klin Wochenschr. 1984; 62(2):81-6.

PMID: 6323814 DOI: 10.1007/BF01769667.

References

GABBAY K, DeLuca K, Fisher Jr J, Mako M, Rubenstein A . Familial hyperproinsulinemia. An autosomal dominant defect. N Engl J Med. 1976; 294(17):911-5. DOI: 10.1056/NEJM197604222941701. View

Melani F, Ryan W, Rubenstein A, Steiner D . Proinsulin secretion by a pancreatic beta-cell adenoma. Proinsulin and C-peptide secretion. N Engl J Med. 1970; 283(14):713-9. DOI: 10.1056/NEJM197010012831401. View

Horwitz D, Rubenstein A . Letter: Insulin suppression. Lancet. 1974; 2(7887):1021. DOI: 10.1016/s0140-6736(74)92126-6. View

Rayfield E, Pulini M, Golub A, Rubenstein A, Horwitz D . Nonautonomous function of a pancreatic insulinoma. J Clin Endocrinol Metab. 1976; 43(6):1307-11. DOI: 10.1210/jcem-43-6-1307. View

Heding L, Rasmussen S . Human C-peptide in normal and diabetic subjects. Diabetologia. 1975; 11(3):201-6. DOI: 10.1007/BF00422322. View

Horwitz D, Rubenstein A, Reynolds C, MOLNAR G, Yanaihara N . Prolonged suppression of insulin release by insulin-induced hypoglycemia: demonstration by C-peptide assay. Horm Metab Res. 1975; 7(6):449-52. DOI: 10.1055/s-0028-1093701. View

Sherman B, Pek S, FAJANS S, FLOYD Jr J, CONN J . Plasma proinsulin in patients with functioning pancreatic islet cell tumors. J Clin Endocrinol Metab. 1972; 35(2):271-80. DOI: 10.1210/jcem-35-2-271. View

SCHENKEIN I, BUEKER E, Helson L, Axelrod F, DANCIS J . Increased nerve-growth-stimulating activity in disseminated neurofibromatosis. N Engl J Med. 1974; 290(11):613-4. DOI: 10.1056/NEJM197403142901108. View

Horwitz D, Starr J, Mako M, BLACKARD W, Rubenstein A . Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood. J Clin Invest. 1975; 55(6):1278-83. PMC: 301883. DOI: 10.1172/JCI108047. View

10.

Turner R, Harris E . Diagnosis of insulinomas by suppression tests. Lancet. 1974; 2(7874):188-90. DOI: 10.1016/s0140-6736(74)91484-6. View

11.

Heding L . Radioimmunological determination of human C-peptide in serum. Diabetologia. 1975; 11(6):541-8. DOI: 10.1007/BF01222104. View

12.

Albano J, Ekins R, Maritz G, Turner R . A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol (Copenh). 1972; 70(3):487-509. DOI: 10.1530/acta.0.0700487. View

13.

Couropmitree C, Freinkel N, Nagel T, Horwitz D, Metzger B, Rubenstein A . Plasma C-peptide and diagnosis of factitious hyperinsulinism. Study of an insulin-dependent diabetic patient with "spontaneous" hypoglycemia. Ann Intern Med. 1975; 82(2):201-4. DOI: 10.7326/0003-4819-82-2-201. View

14.

Gutman R, Lazarus N, PENHOS J, Fajans S, RECANT L . Circulating proinsulin-like material in patients with functioning insulinomas. N Engl J Med. 1971; 284(18):1003-8. DOI: 10.1056/NEJM197105062841803. View

15.

Alsever R, Roberts J, Gerber J, Mako M, Rubenstein A . Insulinoma with low circulating insulin levels: the diagnostic value of proinsulin measurements. Ann Intern Med. 1975; 82(3):347-50. DOI: 10.7326/0003-4819-82-3-347. View

16.

Creutzfeldt W, Arnold R, Creutzfeldt C, DEUTICKE U, Frerichs H, Track N . Biochemical and morphological investigations of 30 human insulinomas. Correlation between the tumour content of insulin and proinsulin-like components and the histological and ultrastructural appearance. Diabetologia. 1973; 9(3):217-31. DOI: 10.1007/BF01219786. View

17.

Frazier W, Angeletti R, Bradshaw R . Nerve growth factor and insulin. Science. 1972; 176(4034):482-8. DOI: 10.1126/science.176.4034.482. View

18.

Lazarus N, Gutman R, PENHOS J, RECANT L . Biologically active circulating proinsulin-like materials from an islet cell carcinoma patient. Diabetologia. 1972; 8(2):131-5. DOI: 10.1007/BF01235638. View

19.

Turner R, Johnson P . Suppression of insulin release by fish-insulin-induced hypoglycaemia: with reference to the diagnosis of insulinomas. Lancet. 1973; 1(7818):1483-5. DOI: 10.1016/s0140-6736(73)91817-5. View

20.

Roth J, Gorden P, Pastan I . "Big insulin": a new component of plasma insulin detected by immunoassay. Proc Natl Acad Sci U S A. 1968; 61(1):138-45. PMC: 285915. DOI: 10.1073/pnas.61.1.138. View