New Insights into T Cell Biology and T Cell-directed Therapy for Autoimmunity, Inflammation, and Immunosuppression

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2010 Feb 12

PMID 20146712

Citations 16

Authors

Scott M Steward-Tharp

Yun-Jeong Song

Richard M Siegel

John J OShea

Affiliations

Soon will be listed here.

Abstract

T cell-directed therapies have become mainstays in the management of various autoimmune diseases and organ transplantation. The understanding of T cell biology has expanded greatly since the development of most agents currently in use. Here we discuss important recent discoveries pertaining to T helper cell differentiation, lineage commitment, and function. Within this context, we examine existing T cell-directed therapies, including new agents being evaluated in clinical and preclinical studies. We also use recent findings to speculate on novel targets.

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