» Articles » PMID: 20117849

Impact of Poor-quality Medicines in the 'developing' World

Overview
Specialty Pharmacology
Date 2010 Feb 2
PMID 20117849
Citations 100
Authors
Affiliations
Soon will be listed here.
Abstract

Since our ancestors began trading several millennia ago, counterfeit and substandard medicines have been a recurring problem, with history punctuated by crises in the supply of anti-microbials, such as fake cinchona bark in the 1600s and fake quinine in the 1800s. Unfortunately this problem persists, in particular afflicting unsuspecting patients in 'developing' countries. Poor-quality drugs are a vital (but neglected) public health problem. They contribute to a 'crevasse' between the enormous effort in therapeutic research and policy decisions and implementation of good-quality medicines.

Citing Articles

Community pharmacy professionals' knowledge, attitudes, and practices toward substandard and falsified medicines and associated factors in Bahir Dar City, Northwest Ethiopia.

Mekonnen B, Berhanu K, Solomon N, Worku M, Anagaw Y Front Pharmacol. 2025; 16:1523709.

PMID: 40070572 PMC: 11893394. DOI: 10.3389/fphar.2025.1523709.


Making intersectoral stakeholder engagement in medicine quality research work: lessons from the STARmeds study in Indonesia.

Hasnida A, Bal R, Manninda R, Saputra S, Nugrahani Y, Faradiba F Health Res Policy Syst. 2025; 23(1):21.

PMID: 39972500 PMC: 11840975. DOI: 10.1186/s12961-025-01286-z.


Prevalence and genetic diversity of polymorphisms in , and genes of in southern Côte d'Ivoire.

Dagnogo O, Ako A, Dago D, Kouman K, Coulibaly N, Bla K Malariaworld J. 2025; 16():1.

PMID: 39803353 PMC: 11716317. DOI: 10.5281/zenodo.14604138.


A narrative review on problems in product quality, regulatory system constraints, and the concept of quality by design as a solution for quality assurance of African medicines.

Hassen H, Mekasha Y, Tegegne A, Ozalp Y Front Med (Lausanne). 2024; 11:1472495.

PMID: 39421861 PMC: 11484627. DOI: 10.3389/fmed.2024.1472495.


Perceived Prevalence, Awareness and Attitude towards Counterfeit Medicines among Community Pharmacists of Kathmandu Valley: A Descriptive Cross-sectional Study.

Kafle S, Jha N, Bhandary S, Shankar P JNMA J Nepal Med Assoc. 2024; 62(275):427-432.

PMID: 39369416 PMC: 11455640. DOI: 10.31729/jnma.8651.


References
1.
Newton P, McGready R, Fernandez F, Green M, Sunjio M, Bruneton C . Manslaughter by fake artesunate in Asia--will Africa be next?. PLoS Med. 2006; 3(6):e197. PMC: 1475657. DOI: 10.1371/journal.pmed.0030197. View

2.
Bate R, Coticelli P, Tren R, Attaran A . Antimalarial drug quality in the most severely malarious parts of Africa - a six country study. PLoS One. 2008; 3(5):e2132. PMC: 2324203. DOI: 10.1371/journal.pone.0002132. View

3.
Laing R, Vrakking H, Fourie B . Quality and stability of TB medicines: let the buyer beware!. Int J Tuberc Lung Dis. 2004; 8(9):1043-4. View

4.
Stepniewska K, White N . Pharmacokinetic determinants of the window of selection for antimalarial drug resistance. Antimicrob Agents Chemother. 2008; 52(5):1589-96. PMC: 2346628. DOI: 10.1128/AAC.00903-07. View

5.
Schwartz E, Regev-Yochay G, Kurnik D . Short report: a consideration of primaquine dose adjustment for radical cure of Plasmodium vivax malaria. Am J Trop Med Hyg. 2000; 62(3):393-5. DOI: 10.4269/ajtmh.2000.62.393. View