Recent Insights into Atopic Dermatitis and Implications for Management of Infectious Complications

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2010 Jan 30

PMID 20109729

Citations 107

Authors

Mark Boguniewicz

Donald Y M Leung

Affiliations

Soon will be listed here.

Abstract

Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes.

Citing Articles

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