Plasma IL-17A is Increased in New-onset SLE Patients and Associated with Disease Activity

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2010 Jan 29

PMID 20107878

Citations 55

Authors

Xiao Qi Chen

Yan Cheng Yu

Hao Hua Deng

Jia Zhong Sun

Zhe Dai

Yu Wen Wu

Miao Yang

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the role of interleukin-17A (IL-17A) and Th17 cell in the pathogenesis of systemic lupus erythematosus (SLE), we studied the plasma IL-17A and the expression of Th17 cell transcription factor RORgammat in Chinese new-onset SLE patients.

Methods: Sixty SLE patients aged between 18 and 40 years and 56 age-matched healthy volunteers were involved in the study. Enzyme-linked immunosorbent assay was used to measure plasma IL-17A level, and rea1-time fluorescent quantitative polymerase chain reaction was used to measure RORgammat mRNA.

Results: The results showed that both IL-17A level and RORgammat mRNA in SLE patients were higher than that of controls. Correlation analysis indicated that plasma IL-17A level was positively correlated with Systemic Lupus Erythematosus Disease Activity Index, not with RORgammat mRNA.

Conclusion: We concluded that IL-17A might play a role in the pathogenesis of SLE and associated with disease activity. RORgammat-determined Th17 cell might be involved with increased IL-17A in SLE but not exclusively the unique source.

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