Omega-3 Fatty Acids and Cognitive Function in Women

Overview

Journal Womens Health (Lond)

Specialty Gynecology & Obstetrics

Date 2010 Jan 22

PMID 20088735

Citations 20

Authors

Jennifer G Robinson

Nkechinyere Ijioma

William Harris

Affiliations

Soon will be listed here.

Abstract

Omega-3 fatty acids (FAs) could play an important role in maintaining cognitive function in aging individuals. The omega-3 FA docosahexaenoic acid is a major constituent of neuronal membranes and, along with the other long-chain omega-3 FAs from fish such as eicosapentaentoic acid, has been shown to have a wide variety of beneficial effects on neuronal functioning, inflammation, oxidation and cell death, as well as on the development of the characteristic pathology of Alzheimer's disease. Omega-3 FAs may prevent vascular dementia via salutary effects on lipids, inflammation, thrombosis and vascular function. Epidemiologic studies have generally supported a protective association between fish and omega-3 FA levels and cognitive decline. Some of the small, short-term, randomized trials of docosahexaenoic acid and/or eicosapentaentoic acid supplementation have found positive effects on some aspects of cognition in older adults who were cognitively intact or had mild cognitive impairment, although little effect was found in participants with Alzheimer's disease. Large, long-term trials in this area are needed.

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References

Al-Hasani H, Joost H . Nutrition-/diet-induced changes in gene expression in white adipose tissue. Best Pract Res Clin Endocrinol Metab. 2005; 19(4):589-603. DOI: 10.1016/j.beem.2005.07.005. View

Hjerkinn E, Seljeflot I, Ellingsen I, Berstad P, Hjermann I, Sandvik L . Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia. Am J Clin Nutr. 2005; 81(3):583-9. DOI: 10.1093/ajcn/81.3.583. View

Nestel P, Shige H, Pomeroy S, Cehun M, Abbey M, Raederstorff D . The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr. 2002; 76(2):326-30. DOI: 10.1093/ajcn/76.2.326. View

Carney R, Freedland K, Rubin E, Rich M, Steinmeyer B, Harris W . Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial. JAMA. 2009; 302(15):1651-7. PMC: 3477788. DOI: 10.1001/jama.2009.1487. View

Bazan N, Scott B . Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses. Ups J Med Sci Suppl. 1990; 48:97-107. View

Goodfellow J, Bellamy M, Ramsey M, Jones C, Lewis M . Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol. 2000; 35(2):265-70. DOI: 10.1016/s0735-1097(99)00548-3. View

Kalmijn S, van Boxtel M, Ocke M, Verschuren W, Kromhout D, Launer L . Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology. 2004; 62(2):275-80. DOI: 10.1212/01.wnl.0000103860.75218.a5. View

Craig M, Murphy D . Oestrogen, cognition and the maturing female brain. J Neuroendocrinol. 2006; 19(1):1-6. DOI: 10.1111/j.1365-2826.2006.01500.x. View

Ansari K, Shoeman D . Arachidonic and docosahexanoic acid content of bovine brain myelin: implications for the pathogenesis of multiple sclerosis. Neurochem Res. 1990; 15(1):7-11. DOI: 10.1007/BF00969177. View

10.

Burdge G, Jones A, Wootton S . Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*. Br J Nutr. 2002; 88(4):355-63. DOI: 10.1079/BJN2002662. View

11.

Dullemeijer C, Durga J, Brouwer I, van de Rest O, Kok F, Brummer R . n 3 fatty acid proportions in plasma and cognitive performance in older adults. Am J Clin Nutr. 2007; 86(5):1479-85. DOI: 10.1093/ajcn/86.5.1479. View

12.

Kelley B, Petersen R . Alzheimer's disease and mild cognitive impairment. Neurol Clin. 2007; 25(3):577-609, v. PMC: 2682228. DOI: 10.1016/j.ncl.2007.03.008. View

13.

Hoozemans J, Veerhuis R, Rozemuller J, Eikelenboom P . Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology. Int J Dev Neurosci. 2005; 24(2-3):157-65. DOI: 10.1016/j.ijdevneu.2005.11.001. View

14.

von Schacky C, Kiefl R, Jendraschak E, Kaminski W . n-3 fatty acids and cysteinyl-leukotriene formation in humans in vitro, ex vivo, and in vivo. J Lab Clin Med. 1993; 121(2):302-9. View

15.

Wisdom N, Callahan J, Hawkins K . The effects of apolipoprotein E on non-impaired cognitive functioning: a meta-analysis. Neurobiol Aging. 2009; 32(1):63-74. DOI: 10.1016/j.neurobiolaging.2009.02.003. View

16.

Erkkila A, Matthan N, Herrington D, Lichtenstein A . Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. J Lipid Res. 2006; 47(12):2814-9. DOI: 10.1194/jlr.P600005-JLR200. View

17.

Whalley L, Deary I, Starr J, Wahle K, Rance K, Bourne V . n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood. Am J Clin Nutr. 2008; 87(2):449-54. DOI: 10.1093/ajcn/87.2.449. View

18.

van Gelder B, Tijhuis M, Kalmijn S, Kromhout D . Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am J Clin Nutr. 2007; 85(4):1142-7. DOI: 10.1093/ajcn/85.4.1142. View

19.

Selkoe D . Alzheimer's disease is a synaptic failure. Science. 2002; 298(5594):789-91. DOI: 10.1126/science.1074069. View

20.

Iso H, Rexrode K, Stampfer M, Manson J, Colditz G, Speizer F . Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA. 2001; 285(3):304-12. DOI: 10.1001/jama.285.3.304. View