Fasting Increases Tobramycin Oral Absorption in Mice

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2010 Jan 21

PMID 20086144

Citations 6

Authors

Luigina De Leo

Nicola Di Toro

Giuliana Decorti

Noelia Malusa

Alessandro Ventura

Tarcisio Not

Affiliations

Soon will be listed here.

Abstract

The pharmacokinetics of the aminoglycoside tobramycin was evaluated after oral administration to fed or fasting (15 h) mice. As expected, under normal feeding conditions, oral absorption was negligible; however, fasting induced a dramatic increase in tobramycin bioavailability. The dual-sugar test with lactulose and l-rhamnose confirmed increased small bowel permeability via the paracellular route in fasting animals. When experiments aimed at increasing the oral bioavailability of hydrophilic compounds are performed, timing of fasting should be extremely accurate.

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