DARPP-32 Binds to Tra2-beta1 and Influences Alternative Splicing

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2010 Jan 16

PMID 20074680

Citations 11

Authors

Natalya Benderska

Kristina Becker

Jean-Antoine Girault

Cord-Michael Becker

Athena Andreadis

Stefan Stamm

Affiliations

Soon will be listed here.

Abstract

The majority of human genes undergo alternative splicing, which is frequently altered in response to physiological stimuli. DARPP-32 (dopamine and cAMP regulated phosphoprotein, 32kDa) is a component of PKA-dependent signaling pathways. Here we show that DARPP-32 binds directly to the splicing factor tra2-beta1 (transformer 2). DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing.

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