Mammary Tumors and Mammary Tumor Virus Expression in Hybrid Mice of Strains C57BL and GR

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1977 Nov 1

PMID 200697

Citations 5

Authors

W E HESTON

W P Parks

Affiliations

Soon will be listed here.

Abstract

Mammary tumorigenesis in genetic crosses between the high mammary tumor incidence GR and the low incidence C57BL mouse strains is highly correlated with murine mammary tumor virus expression in milk. Although the F1 and first backcross females had a mammary tumor incidence which was consistent with a single dominant gene segregation, the tumor incidence in the critical second backcross segregants disproved the single gene hypothesis. Genetic factors were clearly involved in regulation of virus expression which in turn correlated with both tumor incidence and tumor latency; these complex phenotypes are however best explained as threshold or quasicontinuous characters. As predicted from this model, the age specific incidence of mammary tumors showed a broad peak at 14-19 mo of age with no evidence of an early or late phase. Hematopoietic tumors showed no correlation with virus expression or mammary tumorigenesis suggesting different etiologies for these tumors.

Citing Articles

Natural and induced immunity to mouse mammary tumors and the mammary tumor virus (MuMTV).

Stutman O Springer Semin Immunopathol. 1982; 4(4):333-72.

PMID: 6293110 DOI: 10.1007/BF02053739.

Restriction endonuclease mapping of the proviral DNA of the exogenous RIII murine mammary tumor virus.

Etkind P, Szabo P, Sarkar N J Virol. 1982; 41(3):855-67.

PMID: 6284976 PMC: 256822. DOI: 10.1128/JVI.41.3.855-867.1982.

Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain.

Nusse R, de Moes J, Hilkens J, VAN NIE R J Exp Med. 1980; 152(3):712-9.

PMID: 6251153 PMC: 2185924. DOI: 10.1084/jem.152.3.712.

Transfer, by selective breeding, of the pathogenic Mtv-2 endogenous provirus from the GR strain to a wild mouse line free of endogenous and exogenous mouse mammary tumor virus.

Morris D, Young L, Gardner M, Cardiff R J Virol. 1986; 58(2):247-52.

PMID: 3009842 PMC: 252907. DOI: 10.1128/JVI.58.2.247-252.1986.

Natural infection of Swiss mice with mouse mammary tumor virus (MMTV): viral expression in milk and transmission of infection.

Hainaut P, Vaira D, Francois C, Calberg-Bacq C, OSTERRIETH P Arch Virol. 1985; 83(3-4):195-206.

PMID: 2982354 DOI: 10.1007/BF01309916.

References

Noon M, WOLFORD R, Parks W . Expression of mouse mammary tumor viral polypeptides in milks and tissues. J Immunol. 1975; 115(3):653-8. View

Scolnic E, Goldberg R, Parks W . A biochemical and genetic analysis of mammalian RNA-containing sarcoma viruses. Cold Spring Harb Symp Quant Biol. 1975; 39 Pt 2:885-95. DOI: 10.1101/sqb.1974.039.01.103. View

Parks W, Hubbell E, Goldberg R, ONEILL F, Scolnick E . High frequency variation in mammary tumor virus expression in cell culture. Cell. 1976; 8(1):87-93. DOI: 10.1016/0092-8674(76)90189-6. View

HESTON W, Smith B, Parks W . Mouse mammary tumor virus in hybrids from strains C57BL and GR: breeding test of backcross segregants. J Exp Med. 1976; 144(4):1022-30. PMC: 2190442. DOI: 10.1084/jem.144.4.1022. View

VAN NIE R, Verstraeten A, de Moes J . Genetic transmission of mammary tumour virus by GR mice. Int J Cancer. 1977; 19(3):383-90. DOI: 10.1002/ijc.2910190316. View

Drohan W, Kettmann R, Colcher D, Schlom J . Isolation of the mouse mammary tumor virus sequences not transmitted as germinal provirus in the C3H and RIII mouse strains. J Virol. 1977; 21(3):986-95. PMC: 515638. DOI: 10.1128/JVI.21.3.986-995.1977. View

Hartley J, Wolford N, Old L, Rowe W . A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc Natl Acad Sci U S A. 1977; 74(2):789-92. PMC: 392380. DOI: 10.1073/pnas.74.2.789. View

Blair P . Detection by immunodiffusion of mouse mammary tumor virus in milk samples and correlation with tumor development. Cancer Res. 1969; 29(4):745-8. View

Bentvelzen P, DAAMS J, Hageman P, Calafat J . Genetic transmission of viruses that incite mammary tumor in mice. Proc Natl Acad Sci U S A. 1970; 67(1):377-84. PMC: 283215. DOI: 10.1073/pnas.67.1.377. View

10.

CHARNEY J, PULLINGER B, Moore D . Development of an infectivity assay for mouse mammary-tumor virus. J Natl Cancer Inst. 1969; 43(6):1289-96. View

11.

Varmus H, Bishop J, Nowinski R, Sarker N . Mammary tumour virus specific nucleotide sequences in mouse DNA. Nat New Biol. 1972; 238(84):189-91. DOI: 10.1038/newbio238189a0. View

12.

HESTON W, Vlahakis G, Smith G . Mammary gland tumors in substrains C57BL-M and C57BL-He mice. J Natl Cancer Inst. 1972; 49(3):805-12. View

13.

Varmus H, Quintrell N, Medeiros E, Bishop J, Nowinski R, Sarkar N . Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains. J Mol Biol. 1973; 79(4):663-79. DOI: 10.1016/0022-2836(73)90070-3. View

14.

Parks W, Scolnick E, Kozikowski E . Dexamethasone stimulation of murine mammary tumor virus expression: a tissue culture source of virus. Science. 1974; 184(4133):158-60. DOI: 10.1126/science.184.4133.158. View

15.

Nandi S, Helmich C . Transmission of the mammary tumor virus by the GR mouse strain. II. Genetic studies. J Natl Cancer Inst. 1974; 52(5):1567-70. DOI: 10.1093/jnci/52.5.1567. View

16.

Peters R, Rabstein L, Spahn G, MADISON R, HUEBNER R . Incidence of spontaneous neoplasms in breeding and retired breeder BALB-cCr mice throughout the natural life span. Int J Cancer. 1972; 10(2):273-82. DOI: 10.1002/ijc.2910100207. View

17.

Schlom J, Michalides R, Kufe D, Hehlmann R, Spiegelman S, Bentvelzen P . A comparative study of the biologic and molecular basis of murine mammary carcinoma: a model for human breast cancer. J Natl Cancer Inst. 1973; 51(2):541-51. View

18.

VAN NIE R, Dux A . Biological and morphological characteristics of mammary tumors in GR mice. J Natl Cancer Inst. 1971; 46(4):885-97. View

19.

MUHLBOCK O . Note on a new inbred mouse-strain GR-A. Eur J Cancer (1965). 1965; 1(2):123-4. DOI: 10.1016/0014-2964(65)90003-4. View

20.

Dunn T . Normal and pathologic anatomy of the reticular tissue in laboratory mice, with a classification and discussion of neoplasms. J Natl Cancer Inst. 1954; 14(6):1281-433. View