MRNA and Protein Levels for GABAAalpha4, Alpha5, Beta1 and GABABR1 Receptors Are Altered in Brains from Subjects with Autism

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2010 Jan 13

PMID 20066485

Citations 108

Authors

S Hossein Fatemi

Teri J Reutiman

Timothy D Folsom

Robert J Rooney

Diven H Patel

Paul D Thuras

Affiliations

Soon will be listed here.

Abstract

We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA(A) subunits previously associated with autism (GABRalpha4; GABRalpha5; GABRbeta1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRalpha4, GABRalpha5, GABRbeta1) and one demonstrated concordance in cerebellum (GABBetaR1). These results provide further evidence of impairment of GABAergic signaling in autism.

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