GES-13, a Beta-lactamase Variant Possessing Lys-104 and Asn-170 in Pseudomonas Aeruginosa

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2010 Jan 13

PMID 20065056

Citations 11

Authors

S D Kotsakis

C C Papagiannitsis

E Tzelepi

N J Legakis

V Miriagou

L S Tzouvelekis

Affiliations

Soon will be listed here.

Abstract

GES-13 beta-lactamase, a novel GES variant possessing Lys-104 and Asn-170, was identified in Pseudomonas aeruginosa. bla(GES-13) was the single gene cassette of a class 1 integron probably located in the chromosome. GES-13 efficiently hydrolyzed broad-spectrum cephalosporins and aztreonam. Imipenem was a potent inhibitor of GES-13 but was not hydrolyzed at measurable rates.

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