Transcriptional Suppression of Cellular Gene Expression by C-Myc

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1991 Apr 1

PMID 2005911

Citations 18

Authors

B S Yang

T J Geddes

R J Pogulis

B de Crombrugghe

S O Freytag

Affiliations

Soon will be listed here.

Abstract

High levels of c-Myc in mouse 3T3-L1 cells specifically suppress the expression of three collagen genes. This effect is exerted through collagen promoter sequences and requires the leucine zipper motif of c-Myc. Our data suggest that an important aspect of c-Myc transforming activity is the ability to suppress specific cellular gene transcription.

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