ECM-based Materials in Cardiovascular Applications: Inherent Healing Potential and Augmentation of Native Regenerative Processes

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2010 Jan 9

PMID 20057951

Citations 25

Authors

Anna V Piterina

Aidan J Cloonan

Claire L Meaney

Laura M Davis

Anthony Callanan

Michael T Walsh

Tim M McGloughlin

Affiliations

Soon will be listed here.

Abstract

The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced materials composed of decellularised extracellular matrices (ECM) have been shown to promote the healing process via modulation of the host immune response, resistance to bacterial infections, allowing re-innervation and reestablishing homeostasis in the healing region. The physiological balance within the newly developed vascular tissue is maintained via the recreation of correct biorheology and mechanotransduction factors including host immune response, infection control, homing and the attraction of progenitor cells and infiltration by host tissue. Here, we review the progress in this tissue engineering approach, the enhancement potential of ECM materials and future prospects to reach the clinical environment.

Citing Articles

Mobilization of subcutaneous fascia contributes to the vascularization and function of acellular adipose matrix via formation of vascular matrix complex.

Yang H, Xu Y, Cheong S, Xie C, Zhu Y, Xu S Mater Today Bio. 2025; 30:101461.

PMID: 39866780 PMC: 11764388. DOI: 10.1016/j.mtbio.2025.101461.

Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications.

Roberts E, Abdollahi S, Oustadi F, Stephens E, Badv M ACS Mater Au. 2023; 3(5):418-441.

PMID: 38089096 PMC: 10510515. DOI: 10.1021/acsmaterialsau.3c00021.

Physician antibiotic hydration preferences for biologic antibacterial envelopes during cardiac implantable device procedures.

Deering T, Catanzaro J, Woodard D Front Cardiovasc Med. 2023; 9:1006091.

PMID: 36620632 PMC: 9815182. DOI: 10.3389/fcvm.2022.1006091.

Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model.

de Guzman R, Meer A, Mathews A, Israel A, Moses M, Sams C Biomed Mater Eng. 2023; 34(4):289-304.

PMID: 36617774 PMC: 10357198. DOI: 10.3233/BME-221488.

3D printed biomimetic flexible blood vessels with iPS cell-laden hierarchical multilayers.

Hann S, Cui H, Chen G, Boehm M, Esworthy T, Zhang L Biomed Eng Adv. 2022; 4.

PMID: 36582411 PMC: 9794201. DOI: 10.1016/j.bea.2022.100065.

References

Wray C, Mammen J, Hasselgren P . Catabolic response to stress and potential benefits of nutrition support. Nutrition. 2002; 18(11-12):971-7. DOI: 10.1016/s0899-9007(02)00985-1. View

Allman A, McPherson T, Merrill L, Badylak S, Metzger D . The Th2-restricted immune response to xenogeneic small intestinal submucosa does not influence systemic protective immunity to viral and bacterial pathogens. Tissue Eng. 2002; 8(1):53-62. DOI: 10.1089/107632702753503054. View

Ruoslahti E, Reed J . New way to activate caspases. Nature. 1999; 397(6719):479-80. DOI: 10.1038/17229. View

Hoch J, Stark V, Turnipseed W . The temporal relationship between the development of vein graft intimal hyperplasia and growth factor gene expression. J Vasc Surg. 1995; 22(1):51-8. DOI: 10.1016/s0741-5214(95)70088-9. View

Aumailley M, El Khal A, Knoss N, Tunggal L . Laminin 5 processing and its integration into the ECM. Matrix Biol. 2003; 22(1):49-54. DOI: 10.1016/s0945-053x(03)00013-1. View

Gilbert P, Maira-Litran T, McBain A, Rickard A, Whyte F . The physiology and collective recalcitrance of microbial biofilm communities. Adv Microb Physiol. 2002; 46:202-56. View

Roeder R, Wolfe J, Lianakis N, Hinson T, Geddes L, Obermiller J . Compliance, elastic modulus, and burst pressure of small-intestine submucosa (SIS), small-diameter vascular grafts. J Biomed Mater Res. 1999; 47(1):65-70. DOI: 10.1002/(sici)1097-4636(199910)47:1<65::aid-jbm9>3.0.co;2-f. View

Clowes A, Gown A, Hanson S, Reidy M . Mechanisms of arterial graft failure. 1. Role of cellular proliferation in early healing of PTFE prostheses. Am J Pathol. 1985; 118(1):43-54. PMC: 1887858. View

Stotts N, Washington D . Nutrition: a critical component of wound healing. AACN Clin Issues Crit Care Nurs. 1990; 1(3):585-94. DOI: 10.4037/15597768-1990-3014. View

10.

Lee M, Chang P, Dunn J . Evaluation of small intestinal submucosa as scaffolds for intestinal tissue engineering. J Surg Res. 2008; 147(2):168-71. DOI: 10.1016/j.jss.2008.03.012. View

11.

Kallenbach K, Salcher R, Heim A, Karck M, Mignatti P, Haverich A . Inhibition of smooth muscle cell migration and neointima formation in vein grafts by overexpression of matrix metalloproteinase-3. J Vasc Surg. 2009; 49(3):750-8. PMC: 3816542. DOI: 10.1016/j.jvs.2008.11.001. View

12.

Malcarney H, Bonar F, Murrell G . Early inflammatory reaction after rotator cuff repair with a porcine small intestine submucosal implant: a report of 4 cases. Am J Sports Med. 2005; 33(6):907-11. DOI: 10.1177/0363546504271500. View

13.

Somers P, De Somer F, Cornelissen M, Bouchez S, Gasthuys F, Narine K . Genipin blues: an alternative non-toxic crosslinker for heart valves?. J Heart Valve Dis. 2009; 17(6):682-8. View

14.

McFetridge P, Daniel J, Bodamyali T, Horrocks M, Chaudhuri J . Preparation of porcine carotid arteries for vascular tissue engineering applications. J Biomed Mater Res A. 2004; 70(2):224-34. DOI: 10.1002/jbm.a.30060. View

15.

Hopkins R, Jones A, Wolfinbarger L, Moore M, Bert A, Lofland G . Decellularization reduces calcification while improving both durability and 1-year functional results of pulmonary homograft valves in juvenile sheep. J Thorac Cardiovasc Surg. 2009; 137(4):907-13, 913e1-4. DOI: 10.1016/j.jtcvs.2008.12.009. View

16.

Lin K, Hsu P, Chen B, Yuan S, Usami S, Shyy J . Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A. 2000; 97(17):9385-9. PMC: 16873. DOI: 10.1073/pnas.170282597. View

17.

Ginalska G, Kowalczuk D, Osinska M . A chemical method of gentamicin bonding to gelatine-sealed prosthetic vascular grafts. Int J Pharm. 2004; 288(1):131-40. DOI: 10.1016/j.ijpharm.2004.09.021. View

18.

Aldenhoff Y, van der Veen F, Ter Woorst J, Habets J, Poole-Warren L, Koole L . Performance of a polyurethane vascular prosthesis carrying a dipyridamole (Persantin) coating on its lumenal surface. J Biomed Mater Res. 2000; 54(2):224-33. DOI: 10.1002/1097-4636(200102)54:2<224::aid-jbm9>3.0.co;2-e. View

19.

Pelliccia F, Pasceri V, Cianfrocca C, Vitale C, Pristipino C, Speciale G . Endothelial progenitor cells in patients with coronary artery disease and left ventricular dysfunction. Coron Artery Dis. 2009; 20(5):303-8. DOI: 10.1097/MCA.0b013e328325765e. View

20.

Lantz G, Badylak S, Coffey A, Geddes L, Sandusky G . Small intestinal submucosa as a superior vena cava graft in the dog. J Surg Res. 1992; 53(2):175-81. DOI: 10.1016/0022-4804(92)90031-t. View