Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: Cell-based Therapies for Myocardial Repair and Regeneration in Ischemic Heart Disease and Heart Failure

Overview

Journal Eur Heart J

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 2016 Apr 9

PMID 27055812

Citations 123

Authors

Rosalinda Madonna

Linda W van Laake

Sean M Davidson

Felix B Engel

Derek J Hausenloy

Sandrine Lecour

Jonathan Leor

Cinzia Perrino

Rainer Schulz

Kirsti Ytrehus

Ulf Landmesser

Christine L Mummery

Stefan Janssens

James Willerson

Thomas Eschenhagen

Peter Ferdinandy

Joost P G Sluijter

Affiliations

Soon will be listed here.

Abstract

Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Here, we discuss the use of cells in the context of heart repair, and the most relevant results and current limitations from clinical trials using cell-based therapies to treat IHD and HF. We identify and discuss promising potential new therapeutic strategies that include ex vivo cell-mediated gene therapy, the use of biomaterials and cell-free therapies aimed at increasing the success rates of therapy for IHD and HF. The overall aim of this Position Paper of the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to improve the therapeutic application of cell-based therapies for cardiac regeneration and repair.

Citing Articles

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