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Increased Spontaneous Mitotic Segregation in MMS-sensitive Mutants of Saccharomyces Cerevisiae

Overview
Journal Genetics
Publisher Oxford University Press
Specialty Genetics
Date 1977 Oct 1
PMID 200524
Citations 28
Authors
S Prakash
L Prakash
Affiliations
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Abstract

Methyl methanesulfonate (MMS)-sensitive mutants of Saccharomyces cerevisiae belonging to four different complementation groups, when homozygous, increase the rate of spontaneous mitotic segregation to canavanine resistance from heterozygous sensitive (canr/+) diploids by 13-to 170-fold. The mms8-1 mutant is MMS and X-ray sensitive and increases the rate of spontaneous mitotic segregation 170-fold. The mms9-1 and mms13-1 mutants are sensitive to X rays and UV, respectively, in addition of MMS, and increase the rate of spontaneous mitotic segregation by 13-fold and 85-fold, respectively. The mutant mms21-1 is sensitive to MMS, X rays and UV and increases the rate of spontaneous mitotic segregation 23-fold.

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