Schistosoma Mansoni Infection Reduces the Incidence of Murine Cerebral Malaria

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2010 Jan 7

PMID 20051114

Citations 23

Authors

Judith H Waknine-Grinberg

Daniel Gold

Ariel Ohayon

Eliezer Flescher

Alina Heyfets

Michael J Doenhoff

Gabriele Schramm

Helmut Haas

Jacob Golenser

Affiliations

Soon will be listed here.

Abstract

Background: Plasmodium and Schistosoma are two of the most common parasites in tropical areas. Deregulation of the immune response to Plasmodium falciparum, characterized by a Th1 response, leads to cerebral malaria (CM), while a Th2 response accompanies chronic schistosomiasis.

Methods: The development of CM was examined in mice with concomitant Schistosoma mansoni and Plasmodium berghei ANKA infections. The effect of S. mansoni egg antigen injection on disease development and survival was also determined. Cytokine serum levels were estimated using ELISA. Statistical analysis was performed using t-test.

Results: The results demonstrate that concomitant S. mansoni and P. berghei ANKA infection leads to a reduction in CM. This effect is dependent on infection schedule and infecting cercariae number, and is correlated with a Th2 response. Schistosomal egg antigen injection delays the death of Plasmodium-infected mice, indicating immune involvement.

Conclusions: This research supports previous claims of a protective effect of helminth infection on CM development. The presence of multiple parasitic infections in patients from endemic areas should therefore be carefully noted in clinical trials, and in the development of standard treatment protocols for malaria. Defined helminth antigens may be considered for alleviation of immunopathological symptoms.

Citing Articles

Coinfection with Enhances Disease Severity in Human African Trypanosomiasis.

Mitalo N, Waiganjo N, Mokua Mose J, Bosire D, Oula J, Isaac A J Trop Med. 2023; 2023:1063169.

PMID: 37954132 PMC: 10637842. DOI: 10.1155/2023/1063169.

Single-cell RNA sequencing reveals a peripheral landscape of immune cells in Schistosomiasis japonica.

Li J, Zhang Y, Li H, Jiang J, Guo C, Zhou Z Parasit Vectors. 2023; 16(1):356.

PMID: 37817226 PMC: 10563327. DOI: 10.1186/s13071-023-05975-y.

Investigating the outcomes of virus coinfection within and across host species.

Imrie R, Walsh S, Roberts K, Lello J, Longdon B PLoS Pathog. 2023; 19(5):e1011044.

PMID: 37216391 PMC: 10237676. DOI: 10.1371/journal.ppat.1011044.

Infection against infection: parasite antagonism against parasites, viruses and bacteria.

Shen S, Qu X, Zhang W, Li J, Lv Z Infect Dis Poverty. 2019; 8(1):49.

PMID: 31200765 PMC: 6570864. DOI: 10.1186/s40249-019-0560-6.

Associations between soil-transmitted helminthiasis and viral, bacterial, and protozoal enteroinfections: a cross-sectional study in rural Laos.

Chard A, Baker K, Tsai K, Levy K, Sistrunk J, Chang H Parasit Vectors. 2019; 12(1):216.

PMID: 31064387 PMC: 6505259. DOI: 10.1186/s13071-019-3471-2.

References

Dadara A, Lautsch N, Dudek T, Novitsky V, Lee T, Essex M . Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice. Vaccine. 2006; 24(24):5211-9. DOI: 10.1016/j.vaccine.2006.03.078. View

Schramm G, Mohrs K, Wodrich M, Doenhoff M, Pearce E, Haas H . Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J Immunol. 2007; 178(10):6023-7. DOI: 10.4049/jimmunol.178.10.6023. View

Mitchell A, Hansen A, Hee L, Ball H, Potter S, Walker J . Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun. 2005; 73(9):5645-53. PMC: 1231146. DOI: 10.1128/IAI.73.9.5645-5653.2005. View

Curfs J, van der Meide P, Billiau A, Meuwissen J, Eling W . Plasmodium berghei: recombinant interferon-gamma and the development of parasitemia and cerebral lesions in malaria-infected mice. Exp Parasitol. 1993; 77(2):212-23. DOI: 10.1006/expr.1993.1078. View

Hunt N, Grau G . Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol. 2003; 24(9):491-9. DOI: 10.1016/s1471-4906(03)00229-1. View

Engwerda C, Belnoue E, Gruner A, Renia L . Experimental models of cerebral malaria. Curr Top Microbiol Immunol. 2005; 297:103-43. View

Schramm G, Gronow A, Knobloch J, Wippersteg V, Grevelding C, Galle J . IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs. Mol Biochem Parasitol. 2006; 147(1):9-19. DOI: 10.1016/j.molbiopara.2006.01.003. View

Nacher M, Singhasivanon P, Traore B, Vannaphan S, Gay F, Chindanond D . Helminth infections are associated with protection from cerebral malaria and increased nitrogen derivatives concentrations in Thailand. Am J Trop Med Hyg. 2002; 66(3):304-9. DOI: 10.4269/ajtmh.2002.66.304. View

Elliott D, Urban JF J, Argo C, Weinstock J . Does the failure to acquire helminthic parasites predispose to Crohn's disease?. FASEB J. 2000; 14(12):1848-55. DOI: 10.1096/fj.99-0885hyp. View

10.

Pierrot C, Wilson S, Lallet H, Lafitte S, Jones F, Daher W . Identification of a novel antigen of Schistosoma mansoni shared with Plasmodium falciparum and evaluation of different cross-reactive antibody subclasses induced by human schistosomiasis and malaria. Infect Immun. 2006; 74(6):3347-54. PMC: 1479256. DOI: 10.1128/IAI.01724-05. View

11.

Maitland K, Newton C . Acidosis of severe falciparum malaria: heading for a shock?. Trends Parasitol. 2005; 21(1):11-6. DOI: 10.1016/j.pt.2004.10.010. View

12.

Lyke K, Dabo A, Sangare L, Arama C, Daou M, Diarra I . Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection in Malian children. Infect Immun. 2006; 74(10):5718-24. PMC: 1594876. DOI: 10.1128/IAI.01822-05. View

13.

Muturi E, Jacob B, Kim C, Mbogo C, Novak R . Are coinfections of malaria and filariasis of any epidemiological significance?. Parasitol Res. 2007; 102(2):175-81. DOI: 10.1007/s00436-007-0779-1. View

14.

Curfs J, Hermsen C, Meuwissen J, Eling W . Immunization against cerebral pathology in Plasmodium berghei-infected mice. Parasitology. 1992; 105 ( Pt 1):7-14. DOI: 10.1017/s0031182000073625. View

15.

CHRISTENSEN N, Furu P, Kurtzhals J, Odaibo A . Heterologous synergistic interactions in concurrent experimental infection in the mouse with Schistosoma mansoni, Echinostoma revolutum, Plasmodium yoelii, Babesia microti, and Trypanosoma brucei. Parasitol Res. 1988; 74(6):544-51. DOI: 10.1007/BF00531632. View

16.

Casals-Pascual C, Idro R, Gicheru N, Gwer S, Kitsao B, Gitau E . High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria. Proc Natl Acad Sci U S A. 2008; 105(7):2634-9. PMC: 2268188. DOI: 10.1073/pnas.0709715105. View

17.

Hartgers F, Obeng B, Kruize Y, Dijkhuis A, McCall M, Sauerwein R . Responses to malarial antigens are altered in helminth-infected children. J Infect Dis. 2009; 199(10):1528-35. DOI: 10.1086/598687. View

18.

Nacher M . Worms and malaria: blind men feeling the elephant?. Parasitology. 2008; 135(7):861-8. DOI: 10.1017/S0031182008000358. View

19.

Gea-Sorli S, Closa D . In vitro, but not in vivo, reversibility of peritoneal macrophages activation during experimental acute pancreatitis. BMC Immunol. 2009; 10:42. PMC: 2727495. DOI: 10.1186/1471-2172-10-42. View

20.

Sangweme D, Shiff C, Kumar N . Plasmodium yoelii: adverse outcome of non-lethal P. yoelii malaria during co-infection with Schistosoma mansoni in BALB/c mouse model. Exp Parasitol. 2009; 122(3):254-9. PMC: 2703580. DOI: 10.1016/j.exppara.2009.04.003. View