Aziridines As Intermediates in Diversity-oriented Syntheses of Alkaloids

Overview

Journal Tetrahedron Lett

Publisher Elsevier

Specialty Chemistry

Date 2010 Jan 5

PMID 20046991

Citations 11

Authors

Alexander M Taylor

Stuart L Schreiber

Affiliations

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Abstract

The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic heterocycles based on nucleophilic ring opening and subsequent intramolecular cyclization.

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