SNAI1 and SNAI2 Are Asymmetrically Expressed at the 2-cell Stage and Become Segregated to the TE in the Mouse Blastocyst

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2010 Jan 5

PMID 20046880

Citations 10

Authors

Christine E Bell

Andrew J Watson

Affiliations

Soon will be listed here.

Abstract

SNAI1 and SNAI2 are transcription factors that initiate Epithelial-to-Mesenchymal cell transitions throughout development and in cancer metastasis. Here we show novel expression of SNAI1 and SNAI2 throughout mouse preimplantation development revealing asymmetrical localization of both SNAI1 and SNAI2 in individual blastomeres beginning at the 2-cell stage through to the 8-cell stage where SNAI1 and SNAI2 are then only detected in outer cells and not inner cells of the blastocyst. This study implicates SNAI1 and SNAI2 in the lineage segregation of the trophectoderm and inner cell mass, and provides new insight into these oncogenes.

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