Efficiency of Hyaluronic Acid (HA) Sperm Selection

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2009 Dec 31

PMID 20041286

Citations 22

Authors

Lodovico Parmegiani

Graciela Estela Cognigni

Walter Ciampaglia

Patrizia Pocognoli

Francesca Marchi

Marco Filicori

Affiliations

Soon will be listed here.

Abstract

Purpose: Hyaluronic Acid (HA) has a role as "physiologic selector" for spermatozoa prior to intracytoplasmic sperm injection (ICSI). The objective of this study is to analyze the results achievable by the introduction of a routine HA-ICSI programme.

Methods: We retrospectively observed 293 couples treated with HA-ICSI versus 86 couples treated with conventional PVP-ICSI (historical control group). ICSI was performed on a limited number of oocytes per patient (1-3) according to Italian IVF law at the time of the study. Main outcome measures observed were: fertilization, embryo quality, implantation and pregnancy.

Results: This study showed that Injection of HA-bound spermatozoa (HA-ICSI) significantly improves embryo quality and implantation.

Conclusions: If wider multi-center randomized studies will confirm these beneficial effects on ICSI outcome, HA could be considered as a routine choice for "physiologic" sperm selection prior to ICSI.

Citing Articles

Influence of a hyaluronan-binding system for sperm selection in intracytoplasmic sperm injection cycles on embryo morphokinetic parameters and in vitro fertilization cycle outcomes.

Emirdar V, Karatasli V, Tamer B, Pala I, Gunturkun F, Ozbaykus C Arch Gynecol Obstet. 2023; 307(5):1633-1639.

PMID: 36892604 DOI: 10.1007/s00404-023-06992-z.

Sperm selection by the oviduct: perspectives for male fertility and assisted reproductive technologies†.

Soto-Heras S, Sakkas D, Miller D Biol Reprod. 2023; 108(4):538-552.

PMID: 36625382 PMC: 10106845. DOI: 10.1093/biolre/ioac224.

Sperm Adhesion Molecule 1 (SPAM1) Distribution in Selected Human Sperm by Hyaluronic Acid Test.

Gomez-Torres M, Saez-Espinosa P, Manzano-Santiago P, Robles-Gomez L, Huerta-Retamal N, Aizpurua J Biomedicines. 2022; 10(10).

PMID: 36289815 PMC: 9599839. DOI: 10.3390/biomedicines10102553.

Comparison of zeta potential and physiological intracytoplasmic sperm injection in obtaining sperms with a lower DNA fragmentation index: A cross-sectional study.

Vahidi S, Narimani N, Marvast L, Mangoli E, Nabi A, Sadeghi M Int J Reprod Biomed. 2022; 20(5):357-364.

PMID: 35911857 PMC: 9334896. DOI: 10.18502/ijrm.v20i5.11050.

Molecular Chaperone HSPA2 Distribution During Hyaluronic Acid Selection in Human Sperm.

Gomez-Torres M, Huerta-Retamal N, Saez-Espinosa P, Robles-Gomez L, Aviles M, Aizpurua J Reprod Sci. 2022; 30(4):1176-1185.

PMID: 35819578 PMC: 10160204. DOI: 10.1007/s43032-022-01031-9.

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