Gender Differences in Platelet Aggregation in Healthy Individuals

Overview

Journal J Thromb Thrombolysis

Specialty Cardiology & Vascular Diseases

Date 2009 Dec 30

PMID 20039102

Citations 15

Authors

Mohammad Otahbachi

Jan Simoni

Grace Simoni

John F Moeller

Cihan Cevik

Gary E Meyerrose

Chanwit Roongsritong

Affiliations

Soon will be listed here.

Abstract

This study evaluated gender variability in platelet aggregation in response to common agonists. Platelet aggregation was measured in 36 healthy men and women free of any antiplatelet medication, aged 22-36 years, of Caucasian (White not of Hispanic origin), Hispanic, and African-American not of Hispanic origin. In this ex-vivo study, we investigated platelet aggregation in response to adenosine-5'-diphosphate (ADP), epinephrine (EPI), arachidonic acid (AA) and collagen (COL), using a platelet ionized calcium aggregometer (Chrono-Log Co.). Platelet aggregation response to all tested agonists was higher in females than in males regardless of ethnicity. The most significant differences were observed with collagen (P < 0.01). Among the ethnic groups, Caucasian women were most prone to platelet aggregation. Gender is a determinant of agonist effects on platelet aggregability in healthy subjects.

Citing Articles

Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3.

Protty M, Tyrrell V, Hajeyah A, Morgan B, Costa D, Li Y J Lipid Res. 2024; 66(1):100727.

PMID: 39674322 PMC: 11754521. DOI: 10.1016/j.jlr.2024.100727.

Investigation of hematologic findings related to brucellosis in Anatolian region.

Celik M, Arslan Y, Topcu E, Serhat Sahinoglu M, Altindag D, Gurbuz E Saudi Med J. 2024; 45(5):495-501.

PMID: 38734423 PMC: 11147557. DOI: 10.15537/smj.2024.45.5.20230847.

Sex-Specific Acute Cerebrovascular Responses to Photothrombotic Stroke in Mice.

Raman-Nair J, Cron G, MacLeod K, Lacoste B eNeuro. 2024; 11(1).

PMID: 38164600 PMC: 10849032. DOI: 10.1523/ENEURO.0400-22.2023.

Improving the Quality of EDTA-treated Blood Specimens from Mice.

Layssol-Lamour C, Granat F, Sahal A, Braun J, Trumel C, Bourges-Abella N J Am Assoc Lab Anim Sci. 2022; 61(2):188-194.

PMID: 35022109 PMC: 8956217. DOI: 10.30802/AALAS-JAALAS-21-000093.

The risk of major bleeding event in patients with chronic kidney disease on pentoxifylline treatment.

Fang J, Chen Y, Ho C, Chen J, Hsing C, Liang F Sci Rep. 2021; 11(1):13521.

PMID: 34188087 PMC: 8241975. DOI: 10.1038/s41598-021-92753-4.

References

Johnson M, Ramey E, RAMWELL P . Androgen-mediated sensitivity in platelet aggregation. Am J Physiol. 1977; 232(4):H381-5. DOI: 10.1152/ajpheart.1977.232.4.H381. View

Simoni J, Simoni G, Wesson D, Griswold J, Feola M . A novel hemoglobin-adenosine-glutathione based blood substitute: evaluation of its effects on human blood ex vivo. ASAIO J. 2000; 46(6):679-92. DOI: 10.1097/00002480-200011000-00007. View

Viles-Gonzalez J, Fuster V, Corti R, Valdiviezo C, Hutter R, Corda S . Atherosclerosis regression and TP receptor inhibition: effect of S18886 on plaque size and composition--a magnetic resonance imaging study. Eur Heart J. 2005; 26(15):1557-61. DOI: 10.1093/eurheartj/ehi175. View

Jayachandran M, Okano H, Chatrath R, Owen W, McConnell J, Miller V . Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs. J Appl Physiol (1985). 2004; 97(4):1445-52. DOI: 10.1152/japplphysiol.01074.2003. View

Renaud S . Risk factors for coronary heart disease and platelet functions. Adv Exp Med Biol. 1984; 164:129-44. DOI: 10.1007/978-1-4684-8616-2_14. View

Gaines K, Burke G . Ethnic differences in stroke: black-white differences in the United States population. SECORDS Investigators. Southeastern Consortium on Racial Differences in Stroke. Neuroepidemiology. 1995; 14(5):209-39. DOI: 10.1159/000109798. View

Ulrich C, Carlson C, Sibert J, Poole E, Yu J, Wang L . Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure. Hum Mutat. 2005; 26(4):394-5. DOI: 10.1002/humu.9371. View

Becker D, Segal J, Vaidya D, Yanek L, Herrera-Galeano J, Bray P . Sex differences in platelet reactivity and response to low-dose aspirin therapy. JAMA. 2006; 295(12):1420-7. DOI: 10.1001/jama.295.12.1420. View

Haque S, Matsubayashi H, Izumi S, Sugi T, Arai T, Kondo A . Sex difference in platelet aggregation detected by new aggregometry using light scattering. Endocr J. 2001; 48(1):33-41. DOI: 10.1507/endocrj.48.33. View

10.

Rand M, Packham M, Kinlough-Rathbone R, Mustard J . Effects of ethanol on pathways of platelet aggregation in vitro. Thromb Haemost. 1988; 59(3):383-7. View

11.

Kambayashi J, Shinoki N, Nakamura T, Ariyoshi H, Kawasaki T, Sakon M . Prevalence of impaired responsiveness to epinephrine in platelets among Japanese. Thromb Res. 1996; 81(1):85-90. DOI: 10.1016/0049-3848(95)00216-2. View

12.

Renaud S, Morazain R, Godsey F, Dumont E, Thevenon C, Martin J . Nutrients, platelet function and composition in nine groups of French and British farmers. Atherosclerosis. 1986; 60(1):37-48. DOI: 10.1016/0021-9150(86)90085-7. View

13.

Yee D, Sun C, Bergeron A, Dong J, Bray P . Aggregometry detects platelet hyperreactivity in healthy individuals. Blood. 2005; 106(8):2723-9. PMC: 1634759. DOI: 10.1182/blood-2005-03-1290. View

14.

Beyan C, Kaptan K, Ifran A, Savasci S, Ozturk Y, Okmen B . Effect of sex difference on platelet aggregation using an optical method in healthy subjects. Clin Lab Haematol. 2006; 28(1):14-6. DOI: 10.1111/j.1365-2257.2006.00742.x. View

15.

Patel R, Lev E, Vaduganathan M, Guthikonda S, Bergeron A, Maresh K . Platelet reactivity among Asian Indians and Caucasians. Platelets. 2007; 18(4):261-5. DOI: 10.1080/09537100701235716. View

16.

Meade T, Vickers M, Thompson S, Stirling Y, Haines A, Miller G . Epidemiological characteristics of platelet aggregability. Br Med J (Clin Res Ed). 1985; 290(6466):428-32. PMC: 1417797. DOI: 10.1136/bmj.290.6466.428. View

17.

Bertrand E, Cloitre B, Ticolat R, Darracq R, Rain S . [Comparison of platelet activity, fibrinolysis and environmental factors in 50 Africans and 50 Europeans. Role of fish consumption]. Nouv Rev Fr Hematol (1978). 1987; 29(4):237-45. View

18.

Allison G, Lowe G, Rahman K . Aged garlic extract may inhibit aggregation in human platelets by suppressing calcium mobilization. J Nutr. 2006; 136(3 Suppl):789S-792S. DOI: 10.1093/jn/136.3.789S. View

19.

Del Zoppo G, Hallenbeck J . Advances in the vascular pathophysiology of ischemic stroke. Thromb Res. 2000; 98(3):73-81. DOI: 10.1016/s0049-3848(00)00218-8. View

20.

TERRES W, Becker P, Rosenberg A . Changes in cardiovascular risk profile during the cessation of smoking. Am J Med. 1994; 97(3):242-9. DOI: 10.1016/0002-9343(94)90007-8. View