Role of A-type Lamins in Signaling, Transcription, and Chromatin Organization

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2009 Dec 30

PMID 20038676

Citations 149

Authors

Vicente Andres

Jose M Gonzalez

Affiliations

Soon will be listed here.

Abstract

A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of human diseases termed laminopathies, including progeroid syndromes and disorders that primarily affect striated muscle, adipose, bone, and neuronal tissues. In this review, we discuss recent research supporting the concept that lamin A/C and associated nuclear envelope proteins regulate gene expression in health and disease through interplay with signal transduction pathways, transcription factors, and chromatin-associated proteins.

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