Characterization of the Human Neutrophil Alloantigen-3a

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2009 Dec 29

PMID 20037594

Citations 41

Authors

Andreas Greinacher

Jan Wesche

Elke Hammer

Birgitt Furll

Uwe Volker

Angelika Reil

Jurgen Bux

Affiliations

Soon will be listed here.

Abstract

Transfusion-related acute lung injury (TRALI) is a frequent cause of transfusion-associated morbidity and mortality. Severe TRALI is often due to antibodies in blood components directed against the human neutrophil alloantigen-3a (HNA-3a). We show here that the HNA-3a antigen arises from a nucleotide polymorphism in the choline transporter-like protein-2 gene (SLC44A2), with the resulting variation at amino acid position 154 determining the reactivity of the protein with HNA-3a-specific antibodies; the variant with an arginine at this position, rather than a glutamine, constitutes the HNA-3a antigen. The molecular identification of this antigen should facilitate the development of assays for blood donor screening to lower the risk of TRALI.

Citing Articles

Lack of the human choline transporter-like protein SLC44A2 causes hearing impairment and a rare red blood phenotype.

Koehl B, Vrignaud C, Mikdar M, Nair T, Yang L, Landry S EMBO Mol Med. 2023; 15(3):e16320.

PMID: 36695047 PMC: 9994479. DOI: 10.15252/emmm.202216320.

Human neutrophil antigen 3 genotype impacts neutrophil-mediated endothelial cell cytotoxicity in a two-event model of TRALI.

Chiaretti S, Burton M, Hassel P, Radenkovic F, Devikashri N, Sultana A Blood Transfus. 2022; 20(6):465-474.

PMID: 35848624 PMC: 9726621. DOI: 10.2450/2022.0013-22.

Leukocyte-Reactive Antibodies in Female Blood Donors: The Austrian Experience.

Schonbacher M, Aichinger N, Weidner L, Jungbauer C, Grabmer C, Schuha B Transfus Med Hemother. 2021; 48(2):99-108.

PMID: 33976610 PMC: 8077487. DOI: 10.1159/000509946.

Neonatal Immune Incompatibilities between Newborn and Mother.

Arneth B J Clin Med. 2020; 9(5).

PMID: 32422924 PMC: 7291300. DOI: 10.3390/jcm9051470.

Neonatal Alloimmune Neutropenia.

Porcelijn L, de Haas M Transfus Med Hemother. 2019; 45(5):311-316.

PMID: 31049048 PMC: 6489100. DOI: 10.1159/000492949.

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