XRCC1 Polymorphisms and Risk of Colorectal Cancer: a Meta-analysis

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 2009 Dec 25

PMID 20033188

Citations 22

Authors

Bin Wang

Dan Wang

Gang Huang

Chao Zhang

Dong-Hua Xu

Weiping Zhou

Affiliations

Soon will be listed here.

Abstract

Purpose: Previous studies investigating the association between X-ray repair cross-complementation group 1 (XRCC1) polymorphisms and colorectal cancer (CRC) risk has provided inconsistent results. The aim of our study was to clarify the effects of XRCC1variants on CRC risk.

Materials And Methods: We conducted searches of the published literature in PubMed, Embase, and CBM databases up to July 6, 2009. Meta-analysis was performed by critically reviewing 14 studies with a total of 2,776 CRC cases and 4,402 controls on Arg399Gln polymorphism, four studies with a total of 931 CRC cases and 1,547 controls on Arg280His polymorphism, and nine studies with a total of 1,709 CRC cases and 3,233 controls on Arg194Trp polymorphism, respectively. Statistical analysis was performed with the software programs Review Manager (version 5.0.10) and STATA (version 9.2).

Results: No significant association between Arg399Gln polymorphism and CRC risk was observed in both total population analyses and subgroup analyses based on ethnicity (OR(Co-dominant model) = 1.04, 95% CI 0.74-1.45, P (OR) = 0.82; OR(Dominant model) = 1.02, 95% CI 0.80-1.30, P (OR) = 0.88; OR (Recessive model) = 1.04, 95% CI 0.81-1.34, P (OR) = 0.78). Arg280His polymorphism also had no significant association with CRC risk (OR(Co-dominant model) = 0.85, 95% CI 0.32-2.31, P (OR) = 0.76; OR(Dominant model) = 1.11, 95% CI 0.87-1.40, P (OR) = 0.40; OR(Recessive model) = 0.85, 95% CI 0.32-2.31, P (OR) = 0.75). Besides, there was also no evidence of association between Arg194Trp polymorphism and CRC risk (OR(Co-dominant model) = 1.43, 95% CI 0.83-2.48, P (OR) = 0.20; OR(Dominant model) = 1.14, 95% CI 0.87-1.51, P (OR) = 0.34; OR(Recessive model) = 1.32, 95% CI 0.82-2.13, P (OR) = 0.25).

Conclusions: No association is found between the polymorphisms in XRCC1 (Arg399Gln, Arg280His, and Arg194Trp) and risk of colorectal cancer.

Citing Articles

Association between ERCC1 Gene Polymorphism (rs11615) and Colorectal Cancer Susceptibility: A Meta-Analysis of Medical Image Fusion and Safety Applications.

Liu M, Qiu Z, Yang Q Comput Math Methods Med. 2022; 2022:9988513.

PMID: 36277013 PMC: 9586779. DOI: 10.1155/2022/9988513.

The independent and combined effects of selected risk factors and Arg399Gln XRCC1 polymorphism in the risk of colorectal cancer among an Iranian population.

Mehrzad J, Dayyani M, Erfanian-Khorasani M Med J Islam Repub Iran. 2020; 34:75.

PMID: 33306066 PMC: 7711031. DOI: 10.34171/mjiri.34.75.

Distribution of nucleotide variants in the DNA sequence of ERCC1 and XRCC1 genes and the effect of phenotype in patients with gastric cancer.

Asgerov E, Senol O, Guler A, Berdeli A Turk J Gastroenterol. 2019; 30(6):517-523.

PMID: 31144657 PMC: 6565345. DOI: 10.5152/tjg.2019.18100.

Meta-Analysis of the Relationship between XRCC1-Arg399Gln and Arg280His Polymorphisms and the Risk of Prostate Cancer.

Yan J, Wang X, Tao H, Deng Z, Yang W, Lin F Sci Rep. 2015; 5:9905.

PMID: 25927275 PMC: 4415422. DOI: 10.1038/srep09905.

XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis.

Qin C, Xu K, Chen Z, Zhai E, He Y, Song X Tumour Biol. 2015; 36(2):461-6.

PMID: 25582318 DOI: 10.1007/s13277-015-3054-6.

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