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Lack of Involvement of Nucleotide Excision Repair Gene Polymorphisms in Colorectal Cancer

Overview
Journal Br J Cancer
Specialty Oncology
Date 2003 Jul 17
PMID 12865926
Citations 45
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Abstract

DNA repair has an essential role in protecting the genome from damage by endogenous and environmental agents. Polymorphisms in DNA repair genes and differences in repair capacity between individuals have been widely documented. For colorectal cancer, the loss of mismatch repair gene activity is a key genetic determinant. Nucleotide excision repair (NER), recombination repair (RR) and base excision repair (BER) pathways have critical roles in protection against other cancers, and we wished to investigate their role in colorectal cancer. We have compared the frequency of polymorphisms in the NER genes, XPD, XPF, XPG, ERCC1; in the BER gene, XRCC1; and in the RR gene, XRCC3; in colorectal cancer patients and in a control group. No significant associations were found for any of the NER gene polymorphisms or for the XRCC1 polymorphism. The C allele (position 18067) of the XRCC3 gene was weakly but significantly associated with colorectal cancer (odds ratio 1.52, 95% confidence interval 1.04-2.22, P=0.03). For all patients who were heterozygous for any of the repair genes studied, tumour tissue was investigated for loss of heterozygosity (LOH). Only one example of LOH was found for all the genes examined. From the association and LOH data, we conclude that these genes do not have an important role in protection against colorectal carcinogenesis.

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References
1.
Duell E, Holly E, Bracci P, Wiencke J, Kelsey K . A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. Cancer Res. 2002; 62(16):4630-6. View

2.
Chen S, Tang D, Xue K, Xu L, Ma G, Hsu Y . DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. Carcinogenesis. 2002; 23(8):1321-5. DOI: 10.1093/carcin/23.8.1321. View

3.
Stern M, Umbach D, Lunn R, Taylor J . DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2002; 11(9):939-43. View

4.
Park J, Park S, Choi J, Lee S, Jeon H, Cha S . Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 2002; 11(10 Pt 1):993-7. View

5.
Qiao Y, Spitz M, Guo Z, Hadeyati M, Grossman L, Kraemer K . Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes. Mutat Res. 2002; 509(1-2):165-74. DOI: 10.1016/s0027-5107(02)00219-1. View