Modeling Growth and Telomere Dynamics in Saccharomyces Cerevisiae

Overview

Journal J Theor Biol

Publisher Elsevier

Specialty Biology

Date 2009 Dec 19

PMID 20018194

Citations 2

Authors

Peter Olofsson

Alison A Bertuch

Affiliations

Soon will be listed here.

Abstract

A general branching process is proposed to model a population of cells of the yeast Saccharomyces cerevisiae following loss of telomerase. Previously published experimental data indicate that a population of telomerase-deficient cells regain exponential growth after a period of slowing due to critical telomere shortening. The explanation for this phenomenon is that some cells engage telomerase-independent pathways to maintain telomeres that allow them to become "survivors." Our model takes into account random variation in individual cell cycle times, telomere length, finite replicative lifespan of mother cells, and survivorship. We identify and estimate crucial parameters such as the probability of an individual cell becoming a survivor, and compare our model predictions to experimental data.

Citing Articles

The asymmetry of telomere replication contributes to replicative senescence heterogeneity.

Bourgeron T, Xu Z, Doumic M, Teixeira M Sci Rep. 2015; 5:15326.

PMID: 26468778 PMC: 4606794. DOI: 10.1038/srep15326.

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs.

Hirt B, Wattis J, Preston S J Math Biol. 2013; 68(6):1521-52.

PMID: 23620229 PMC: 3975128. DOI: 10.1007/s00285-013-0678-2.

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